Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC2A1 | P11166 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.47 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.47 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | CNR1 | P21554 | 2/20 | 0.46 |
| ▸ | FPR2 | P25090 | 1/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.45 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.45 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11953344 | 0.86 | CHRM2 (0.57) | CYP11B1CYP11B2MAPTLMNAKMT2A | |
| SCHEMBL7155267 | 0.85 | HDAC3 (0.56) | GAACYP1A2CYP2D6CYP2C19CYP11B1 | |
| SCHEMBL28467893 | 0.84 | CA12 (0.60) | KMT2AATMCA12CA7CA9 | |
| SCHEMBL27909851 | 0.84 | HDAC3 (0.63) | CYP11B1CYP11B2MAPTHDAC3HDAC4 | |
| SCHEMBL9544244 | 0.83 | CYP1A2 (0.51) | GAACYP1A2CYP2D6CYP2C19TAAR1 | |
| SCHEMBL197699 | 0.82 | CYP11B1 (0.58) | GAACYP1A2CYP2D6CYP2C19CYP11B1 | |
| Cyclopropane SCHEMBL11851783 | 0.80 | HDAC3 (0.58) | GAACYP11B1CYP11B2MAPTHDAC3 | |
| SCHEMBL19438542 | 0.80 | SIGMAR1 (0.59) | LMNAKMT2AATMCA12CA7 | |
| SCHEMBL25987670 | 0.79 | ADRB2 (0.57) | CYP1A2MAPTLMNAKMT2AALDH1A1 | |
| SCHEMBL8829830 | 0.79 | SIGMAR1 (0.60) | LMNAKMT2ACA12CA7CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2665704-A1 | AZETIDINE DERIVATIVES USEFUL FOR THE TREATMENT OF METABOLIC AND INFLAMMATORY DISEASES | Galapagos NV (BE) | 2013-11-27 | — | — | EP | disclosed |
| WO-2012098033-A1 | AZETIDINE DERIVATIVES USEFUL FOR THE TREATMENT OF METABOLIC AND INFLAMMATORY DISEASES | GALAPAGOS NV (BE) | 2012-07-26 | — | — | WO | disclosed |