Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 1.00 |
| ▸ | HPGD | P15428 | 4/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 1.00 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.73 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.73 |
| ▸ | PPARG | P37231 | 1/20 | 0.73 |
| ▸ | STAT3 | P40763 | 1/20 | 0.73 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.73 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.73 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.72 |
| ▸ | ADORA2A | P29274 | 9/20 | 0.71 |
| ▸ | ADORA1 | P30542 | 8/20 | 0.71 |
| ▸ | MAPT | P10636 | 2/20 | 0.63 |
| ▸ | GLA | P06280 | 2/20 | 0.63 |
| ▸ | GAA | P10253 | 2/20 | 0.63 |
| ▸ | LMNA | P02545 | 1/20 | 0.63 |
| ▸ | PKM | P14618 | 1/20 | 0.63 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.63 |
| ▸ | CASP1 | P29466 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14176622 | 0.87 | KDM4E (0.77) | KDM4EALDH1A1HPGDHSD17B10RXFP1 | |
| SCHEMBL11125327 | 0.86 | KDM4E (0.75) | KDM4EALDH1A1HPGDHSD17B10RXFP1 | |
| SCHEMBL6253909 | 0.84 | KDM4E (0.74) | KDM4EALDH1A1HPGDHSD17B10RXFP1 | |
| SCHEMBL31120336 | 0.83 | ADORA1 (1.00) | KDM4EALDH1A1HPGDHSD17B10NPSR1 | |
| SCHEMBL4911494 | 0.83 | ADORA1 (1.00) | KDM4EALDH1A1HPGDHSD17B10NPSR1 | |
| SCHEMBL31120420 | 0.82 | ADORA1 (1.00) | KDM4EALDH1A1HPGDHSD17B10NPSR1 | |
| SCHEMBL22208383 | 0.82 | ADORA1 (1.00) | KDM4EALDH1A1HPGDHSD17B10NPSR1 | |
| SCHEMBL31120383 | 0.82 | ADORA1 (1.00) | KDM4EALDH1A1HPGDHSD17B10NPSR1 | |
| SCHEMBL31350444 | 0.81 | ALDH1A1 (0.68) | KDM4EALDH1A1HPGDHSD17B10RXFP1 | |
| SCHEMBL31350615 | 0.81 | HPGD (0.68) | KDM4EALDH1A1HPGDHSD17B10RXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9487486-B2 | Derivatives of nicotinic acid N-oxide, their preparation and their use as inhibitors of enzyme 3-hydroxyanthranilate-3, 4-dioxygenase | UNIVERSITY OF MARYLAND, BALTIMORE (US) | 2016-11-08 | — | — | US | disclosed |
| US-20160052886-A1 | DERIVATIVES OF NICOTINIC ACID N-OXIDE, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF ENZYME 3-HYDROXYANTHRANILATE-3, 4-DIOXYGENASE | UNIVERSITY OF MARYLAND, BALTIMORE | 2016-02-25 | — | — | US | disclosed |
| US-9260394-B2 | Derivatives of nicotinic acid N-oxide, their preparation and their use as inhibitors of enzyme 3-hydroxyanthranilate-3, 4-dioxygenase | UNIVERSITY OF MARYLAND, BALTIMORE (US) | 2016-02-16 | — | — | US | disclosed |
| US-20130289081-A1 | DERIVATIVES OF NICOTINIC ACID N-OXIDE, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF ENZYME 3-HYDROXYANTHRANILATE-3, 4-DIOXYGENASE | UNIVERSITA' DEGLI DI PARMA (IT) | 2013-10-31 | — | — | US | disclosed |
| WO-2012097869-A1 | DERIVATIVES OF NICOTINIC ACID N-OXIDE, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF ENZYME 3-HYDROXYANTHRANILATE-3,4-DIOXYGENASE | UNIVERSITA' DEGLI STUDI DI PARMA (IT) | 2012-07-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160052886-A1 | DERIVATIVES OF NICOTINIC ACID N-OXIDE, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF ENZYME 3-HYDROXYANTHRANILATE-3, 4-DIOXYGENASE | HAAO, NQO2, HAO1 | KDM4E 2416/4885ALDH1A1 245/4885HPGD 22/4885 |
| US-20130289081-A1 | DERIVATIVES OF NICOTINIC ACID N-OXIDE, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF ENZYME 3-HYDROXYANTHRANILATE-3, 4-DIOXYGENASE | HAAO, NQO2, HAO1 | KDM4E 2416/4885ALDH1A1 245/4885HPGD 22/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.