SCHEMBL11297852

SCHEMBL11297852

CCCC[C@@](C)(C(=O)O)C(F)(F)F

nearest known ligand 0.39

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
CES2 O00748 3/20 0.39
FAAH O00519 8/20 0.39
CES1 P23141 5/20 0.38
MEN1 O00255 1/20 0.38
CYP1A2 P05177 1/20 0.38
KMT2A Q03164 1/20 0.38
HSD17B10 Q99714 1/20 0.38
LPAR1 Q92633 1/20 0.35
LPAR3 Q9UBY5 1/20 0.35
AKR1B1 P15121 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11301629 1.00 CES2 (0.39) CES2FAAHCES1MEN1CYP1A2
SCHEMBL9100047 1.00 CES2 (0.39) CES2FAAHCES1MEN1CYP1A2
SCHEMBL9101764 0.94 CES2 (0.47) CES2FAAHCES1MEN1CYP1A2
SCHEMBL9101466 0.92 CES2 (0.50) CES2FAAHCES1MEN1CYP1A2
SCHEMBL9098440 0.92 CES2 (0.50) CES2FAAHCES1MEN1CYP1A2
SCHEMBL9102150 0.86 CES2 (0.33) CES2FAAHCES1MEN1CYP1A2
SCHEMBL13517353 0.86 AKR1B1 (0.40) MEN1KMT2AHSD17B10AKR1B1
SCHEMBL7825590 0.79 CES2 (0.43) CES2FAAHCES1MEN1CYP1A2
SCHEMBL7825586 0.79 CES2 (0.43) CES2FAAHCES1MEN1CYP1A2
Ammonia Solution, Strong SCHEMBL27621075 0.78 AKR1B1 (0.34) MEN1KMT2AHSD17B10AKR1B1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4256911-A TRIFLUOROMETHYL-CARBOXY ESTERS HOFFMANN-LA ROCHE INC. (US) 1981-03-17 US disclosed
US-4237276-A CARDIOVASCULAR AGENTS, INDUCTION OF LABOR, TERMINATION OF PREGNANCY HOFFMANN-LA ROCHE INC. (US) 1980-12-02 US disclosed
US-4211724-A ENANTIOMORPHS, INTERMEDIATE AMIDES WITH ASSYMETRIC CARBON ATOM HOFFMAN-LA ROCHE INC. (US) 1980-07-08 US disclosed
US-4190587-A PROSTAGLANDINS HOFFMANN-LA ROCHE INC. (US) 1980-02-26 US disclosed
US-4187381-A CARDIOVASCULAR AGENTS; OXYTOCICS HOFFMANN-LA ROCHE INC. (US) 1980-02-05 US disclosed
US-4112225-A 16-CF3 prostaglandins HOFFMAN-LA ROCHE INC. (US) 1978-09-05 US disclosed