Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | CNR2 | P34972 | 11/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5754979 | 0.78 | ALDH1A1 (0.61) | KDM4EPKMCNR2MEN1NPC1 | |
| Mopidralazine SCHEMBL2109925 | 0.78 | KDM4E (0.53) | KDM4EPKMCNR2MEN1NPC1 | |
| SCHEMBL16840723 | 0.78 | KDM4E (0.56) | KDM4EPKMCNR2MEN1NPC1 | |
| SCHEMBL10970673 | 0.78 | KDM4E (0.56) | KDM4EPKMCNR2MEN1NPC1 | |
| Hydrochloric Acid SCHEMBL11192350 | 0.76 | KDM4E (0.55) | KDM4EPKMCNR2MEN1NPC1 | |
| SCHEMBL11171300 | 0.74 | KDM4E (0.47) | KDM4EPKMCNR2MEN1NPC1 | |
| SCHEMBL23768195 | 0.74 | KDM4E (0.52) | KDM4EPKMCNR2MEN1NPC1 | |
| SCHEMBL23750482 | 0.72 | KDM4E (0.50) | KDM4EPKMCNR2MEN1NPC1 | |
| Sulfuric Acid SCHEMBL11167741 | 0.71 | KDM4E (0.59) | KDM4EPKMCNR2MEN1NPC1 | |
| SCHEMBL22970904 | 0.69 | CDK4 (0.49) | KDM4EPKMCNR2MEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4247551-A | N-Pyrrolyl-pyridazineamines and their use as antihypertensive agents | GRUPPO LEPETIT S.P.A. (IT) | 1981-01-27 | — | — | US | disclosed |
| EP-0009655-A1 | 6-Amino substituted N-pyrrolyl-3-pyridazine amines, their preparation, and pharmaceutically antihypertensive compositions containing them | GRUPPO LEPETIT S.P.A. (IT) | 1980-04-16 | — | — | EP | disclosed |