Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | CNR2 | P34972 | 7/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.41 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10970673 | 0.80 | KDM4E (0.56) | KDM4EPKMALDH1A1SMN1; SMN2HTT | |
| Hydrochloric Acid SCHEMBL11192350 | 0.78 | KDM4E (0.55) | KDM4EPKMALDH1A1SMN1; SMN2HTT | |
| SCHEMBL5754979 | 0.77 | ALDH1A1 (0.61) | KDM4EPKMALDH1A1SMN1; SMN2HTT | |
| SCHEMBL16840723 | 0.76 | KDM4E (0.56) | KDM4EPKMALDH1A1SMN1; SMN2HTT | |
| SCHEMBL7683687 | 0.74 | PIK3CB (0.39) | PKMALDH1A1HTTMEN1KMT2A | |
| SCHEMBL23768195 | 0.73 | KDM4E (0.52) | KDM4EPKMALDH1A1SMN1; SMN2HTT | |
| SCHEMBL1089586 | 0.72 | CXCR4 (0.74) | PIK3CBCXCR4 | |
| Sulfuric Acid SCHEMBL11167741 | 0.72 | KDM4E (0.59) | KDM4EPKMALDH1A1SMN1; SMN2HTT | |
| SCHEMBL11298447 | 0.72 | KDM4E (0.54) | KDM4EPKMALDH1A1SMN1; SMN2HTT | |
| SCHEMBL106639 | 0.71 | MEN1 (0.54) | KDM4EPKMALDH1A1SMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210246113-A1 | SMALL MOLECULE MODULATORS OF PANTOTHENATE KINASES | ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC. | 2021-08-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210246113-A1 | SMALL MOLECULE MODULATORS OF PANTOTHENATE KINASES | PANK2, PANK1, PANK3 | KDM4E 2299/4885PKM 133/4885ALDH1A1 4262/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.