Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGAM | O43451 | 1/20 | 0.52 |
| ▸ | KDR | P35968 | 2/20 | 0.49 |
| ▸ | LCK | P06239 | 1/20 | 0.49 |
| ▸ | TEK | Q02763 | 1/20 | 0.49 |
| ▸ | ABL1 | P00519 | 1/20 | 0.48 |
| ▸ | BCR | P11274 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | TRPM8 | Q7Z2W7 | 3/20 | 0.44 |
| ▸ | ACACB | O00763 | 1/20 | 0.43 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.41 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.39 |
| ▸ | BCAT1 | P54687 | 1/20 | 0.39 |
| ▸ | TOP2A | P11388 | 1/20 | 0.39 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.38 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.38 |
| ▸ | CFTR | P13569 | 1/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15363972 | 0.86 | KDR (0.53) | MGAMKDRLCKTEKABL1 | |
| SCHEMBL29722360 | 0.85 | ABL1 (0.64) | MGAMKDRLCKTEKABL1 | |
| SCHEMBL11298523 | 0.85 | ABL1 (0.64) | MGAMKDRLCKTEKABL1 | |
| SCHEMBL11305247 | 0.82 | PDGFRB (0.51) | MGAMKDRLCKTEKABL1 | |
| SCHEMBL11319098 | 0.77 | ABL1 (0.85) | KDRLCKTEKABL1BCR | |
| SCHEMBL11297514 | 0.76 | ABL1 (0.64) | MGAMKDRLCKTEKABL1 | |
| SCHEMBL11339717 | 0.75 | TEK (0.49) | KDRLCKTEKABL1BCR | |
| SCHEMBL2255932 | 0.74 | ALDH1A1 (0.44) | MGAMKDRLCKTEKABL1 | |
| SCHEMBL22854596 | 0.74 | PTGDR2 (0.48) | ALDH1A1HAO1 | |
| SCHEMBL15363890 | 0.74 | ABL1 (0.75) | KDRLCKTEKABL1BCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2665709-B1 | DIARYLACETYLENE HYDRAZIDE CONTAINING TYROSINE KINASE INHIBITORS | SUN PHARMA ADVANCED RES CO LTD (IN) | 2016-12-07 | — | — | EP | disclosed |
| US-9024021-B2 | Diarylacetylene hydrazide containing tyrosine kinase inhibitors | SUN PHARMA ADVANCED RESEARCH COMPANY LTD. (IN) | 2015-05-05 | — | — | US | disclosed |
| EP-2665709-A1 | DIARYLACETYLENE HYDRAZIDE CONTAINING TYROSINE KINASE INHIBITORS | Sun Pharma Advanced Research Company Limited (IN) | 2013-11-27 | — | — | EP | disclosed |
| US-20130296557-A1 | DIARYLACETYLENE HYDRAZIDE CONTAINING TYROSINE KINASE INHIBITORS | SUN PHARMA ADVANCED RESEARCH COMPANY LTD. (IN) | 2013-11-07 | — | — | US | disclosed |
| WO-2012098416-A1 | DIARYLACETYLENE HYDRAZIDE CONTAINING TYROSINE KINASE INHIBITORS | SUN PHARMA ADVANCED RESEARCH COMPANY LTD (IN) | 2012-07-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130296557-A1 | DIARYLACETYLENE HYDRAZIDE CONTAINING TYROSINE KINASE INHIBITORS | ABL1, LCK, JAK2 | MGAM 2634/4885KDR 277/4885LCK 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.