Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | TNKS | O95271 | 1/20 | 0.39 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | KRAS | P01116 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11194691 | 0.85 | POLB (0.52) | TOP2ANPC1RAB9APOLBMAPT | |
| SCHEMBL11186679 | 0.82 | POLB (0.42) | TOP2ANPC1RAB9APOLBMAPT | |
| SCHEMBL11183138 | 0.82 | EGFR (0.43) | TOP2ANPC1RAB9APOLBMAPT | |
| SCHEMBL11286093 | 0.78 | MYC (0.50) | POLBMAPTKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL11178712 | 0.76 | POLB (0.55) | POLBMAPTKDM4EALDH1A1MEN1 | |
| SCHEMBL11164561 | 0.74 | MAPT (0.46) | NPC1RAB9APOLBMAPTSMN1; SMN2 | |
| SCHEMBL11164525 | 0.74 | MAPT (0.46) | NPC1RAB9APOLBMAPTSMN1; SMN2 | |
| SCHEMBL11441498 | 0.74 | MCHR1 (0.56) | NPC1RAB9APOLBMAPTSMN1; SMN2 | |
| SCHEMBL11199912 | 0.73 | NPC1 (0.45) | NPC1RAB9APOLBMAPTPTGDR2 | |
| SCHEMBL11190019 | 0.73 | MAPT (0.45) | NPC1RAB9AMAPTSMN1; SMN2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0056144-A1 | Carboxylic acid derivatives, their preparation and use as pharmaceuticals | Dr. Karl Thomae GmbH (DE) | 1982-07-21 | — | — | EP | disclosed |