Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | TOP2A | P11388 | 2/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | TNKS | O95271 | 1/20 | 0.39 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11199855 | 0.89 | DNMT3A (0.48) | POLBMAPTLMNA | |
| SCHEMBL11194691 | 0.85 | POLB (0.52) | POLBTOP2AMAPTALDH1A1NPC1 | |
| SCHEMBL11298652 | 0.82 | TOP2A (0.41) | POLBTOP2AMAPTPTGDR2SMN1; SMN2 | |
| SCHEMBL11183138 | 0.79 | EGFR (0.43) | POLBTOP2AMAPTOPRM1OPRD1 | |
| SCHEMBL11102512 | 0.79 | MYC (0.50) | MAPTOPRK1SMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL11191065 | 0.78 | MAPT (0.54) | POLBMAPTSMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL11193056 | 0.77 | MAPT (0.46) | POLBMAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL11178712 | 0.76 | POLB (0.55) | POLBMAPTALDH1A1TSHRCYP2D6 | |
| SCHEMBL11182439 | 0.76 | LMNA (0.48) | POLBMAPTPTGDR2SMN1; SMN2NPC1 | |
| SCHEMBL11214411 | 0.76 | LMNA (0.43) | POLBMAPTNPC1RAB9ATNKS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0023569-B1 | DERIVATIVES OF CARBOXYLIC ACIDS, THEIR PREPARATION AND MEDICAMENTS CONTAINING THEM | Dr. Karl Thomae GmbH (DE) | 1983-06-22 | — | — | EP | disclosed |
| EP-0023569-A1 | Derivatives of carboxylic acids, their preparation and medicaments containing them | Dr. Karl Thomae GmbH (DE) | 1981-02-11 | — | — | EP | disclosed |