Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.46 |
| ▸ | GMNN | O75496 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.46 |
| ▸ | BLM | P54132 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL16990768 | 0.98 | CES2 (0.50) | CES2MAPK1GMNNLMNAMAPT | |
| Hydrochloric Acid SCHEMBL7561213 | 0.98 | CES2 (0.50) | CES2MAPK1GMNNLMNAMAPT | |
| Hydrochloric Acid SCHEMBL9632302 | 0.98 | CES2 (0.50) | CES2MAPK1GMNNLMNAMAPT | |
| Hydrochloric Acid SCHEMBL5316145 | 0.98 | CES2 (0.46) | CES2MAPK1GMNNLMNAMAPT | |
| SCHEMBL9631685 | 0.98 | CES2 (0.48) | CES2MAPK1GMNNLMNAMAPT | |
| Hydrochloric Acid SCHEMBL5316381 | 0.96 | CES2 (0.48) | CES2MAPK1GMNNLMNAMAPT | |
| Hydrochloric Acid SCHEMBL5317631 | 0.96 | CES2 (0.48) | CES2MAPK1GMNNLMNAMAPT | |
| Hydrochloric Acid SCHEMBL5316578 | 0.96 | CES2 (0.48) | CES2MAPK1GMNNLMNAMAPT | |
| Water SCHEMBL16968728 | 0.96 | CES2 (0.48) | CES2MAPK1GMNNLMNAMAPT | |
| SCHEMBL9632303 | 0.96 | CES2 (0.52) | CES2MAPK1GMNNLMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4289831-A | QUATERNARY AMMONIUM SALT ANTISTATIC LAYER, MODULUS IMPROVER | IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) | 1981-09-15 | — | — | US | disclosed |
| EP-0004151-B1 | ANTISTATIC FILMS | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1981-05-27 | — | — | EP | disclosed |
| US-4268583-A | PACKAGING MATERIALS | IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) | 1981-05-19 | — | — | US | disclosed |
| US-4241144-A | POLYOXYALKYLENE AMINE SULFATE VOLATILE CASTING VEHICLE AND A QUATERNARY AMMONIUM PROVIDES ANTISTATICS | IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) | 1980-12-23 | — | — | US | disclosed |
| EP-0004151-A1 | Antistatic films | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1979-09-19 | — | — | EP | disclosed |