Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 12/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 13/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 11/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.39 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11299059 | 0.81 | HDAC6 (0.48) | HDAC1HDAC6HDAC8HDAC4HDAC2 | |
| SCHEMBL11301463 | 0.79 | HDAC6 (0.42) | HDAC1HDAC6HDAC8HDAC4HDAC2 | |
| SCHEMBL11372589 | 0.79 | HDAC1 (0.48) | HDAC1HDAC6HDAC8HDAC4HDAC2 | |
| SCHEMBL11301919 | 0.79 | HDAC1 (0.48) | HDAC1HDAC6HDAC8HDAC4HDAC2 | |
| SCHEMBL11297190 | 0.79 | HDAC6 (0.44) | HDAC1HDAC6HDAC8HDAC4HDAC2 | |
| SCHEMBL11299544 | 0.78 | HDAC1 (0.43) | HDAC1HDAC6HDAC8HDAC4HDAC2 | |
| SCHEMBL11299511 | 0.74 | HDAC8 (0.41) | HDAC1HDAC6HDAC8HDAC4HDAC2 | |
| SCHEMBL11303189 | 0.71 | HDAC1 (0.39) | HDAC1HDAC6HDAC8HDAC4HDAC2 | |
| SCHEMBL11297461 | 0.71 | HDAC8 (0.37) | HDAC1HDAC6HDAC8HDAC2HDAC3 | |
| SCHEMBL11303497 | 0.71 | HDAC8 (0.46) | HDAC1HDAC6HDAC8HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2665706-A1 | NOVEL 4-AMINO-N-HYDROXY-BENZAMIDES AS HDAC INHIBITORS FOR THE TREATMENT OF CANCER | F.HOFFMANN-LA ROCHE AG (CH) | 2013-11-27 | — | — | EP | claimed |
| WO-2012098132-A1 | NOVEL 4-AMINO-N-HYDROXY-BENZAMIDES AS HDAC INHIBITORS FOR THE TREATMENT OF CANCER | F. HOFFMANN-LA ROCHE AG (CH) | 2012-07-26 | — | — | WO | claimed |
| EP-2665706-A1 | NOVEL 4-AMINO-N-HYDROXY-BENZAMIDES AS HDAC INHIBITORS FOR THE TREATMENT OF CANCER | F.HOFFMANN-LA ROCHE AG (CH) | 2013-11-27 | — | — | EP | disclosed |
| WO-2012098132-A1 | NOVEL 4-AMINO-N-HYDROXY-BENZAMIDES AS HDAC INHIBITORS FOR THE TREATMENT OF CANCER | F. HOFFMANN-LA ROCHE AG (CH) | 2012-07-26 | — | — | WO | disclosed |