Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 13/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 10/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 6/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.38 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.37 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.37 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.37 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.37 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.37 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11301397 | 0.89 | HDAC1 (0.39) | HDAC6HDAC1HDAC8HDAC3HDAC2 | |
| SCHEMBL11301754 | 0.87 | PSEN1 (0.42) | HDAC6HDAC1HDAC8HDAC2PSEN1 | |
| SCHEMBL11306357 | 0.85 | ALDH1A1 (0.46) | HDAC6HDAC1HDAC8SMN1; SMN2NPC1 | |
| SCHEMBL11305647 | 0.84 | HDAC6 (0.41) | HDAC6HDAC1HDAC8NPC1RAB9A | |
| SCHEMBL11303328 | 0.84 | HDAC8 (0.37) | HDAC6HDAC1HDAC8RAB9APSEN1 | |
| SCHEMBL11297375 | 0.83 | HDAC8 (0.44) | HDAC6HDAC1HDAC8NPC1HDAC3 | |
| SCHEMBL11296595 | 0.83 | HDAC6 (0.42) | HDAC6HDAC1HDAC8HDAC3HDAC2 | |
| SCHEMBL11296107 | 0.83 | HDAC8 (0.45) | HDAC6HDAC1HDAC8RAB9AHDAC3 | |
| SCHEMBL11296049 | 0.82 | HDAC6 (0.45) | HDAC6HDAC1HDAC8NPC1RAB9A | |
| SCHEMBL11304336 | 0.82 | HDAC6 (0.42) | HDAC6HDAC1HDAC8HDAC3HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2665706-A1 | NOVEL 4-AMINO-N-HYDROXY-BENZAMIDES AS HDAC INHIBITORS FOR THE TREATMENT OF CANCER | F.HOFFMANN-LA ROCHE AG (CH) | 2013-11-27 | — | — | EP | claimed |
| WO-2012098132-A1 | NOVEL 4-AMINO-N-HYDROXY-BENZAMIDES AS HDAC INHIBITORS FOR THE TREATMENT OF CANCER | F. HOFFMANN-LA ROCHE AG (CH) | 2012-07-26 | — | — | WO | claimed |
| EP-2665706-A1 | NOVEL 4-AMINO-N-HYDROXY-BENZAMIDES AS HDAC INHIBITORS FOR THE TREATMENT OF CANCER | F.HOFFMANN-LA ROCHE AG (CH) | 2013-11-27 | — | — | EP | disclosed |
| WO-2012098132-A1 | NOVEL 4-AMINO-N-HYDROXY-BENZAMIDES AS HDAC INHIBITORS FOR THE TREATMENT OF CANCER | F. HOFFMANN-LA ROCHE AG (CH) | 2012-07-26 | — | — | WO | disclosed |