Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | CES2 | O00748 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13637440 | 1.00 | SMN1; SMN2 (0.35) | SMN1; SMN2THRBALOX15CES2 | |
| SCHEMBL11300063 | 1.00 | SMN1; SMN2 (0.35) | SMN1; SMN2THRBALOX15CES2 | |
| SCHEMBL16976913 | 0.83 | THRB (0.40) | SMN1; SMN2THRBALOX15 | |
| SCHEMBL13627274 | 0.83 | THRB (0.40) | SMN1; SMN2THRBALOX15 | |
| SCHEMBL12087571 | 0.83 | THRB (0.40) | SMN1; SMN2THRBALOX15 | |
| SCHEMBL13627273 | 0.77 | RAB9A (0.37) | SMN1; SMN2THRBALOX15 | |
| SCHEMBL16976910 | 0.77 | RAB9A (0.37) | SMN1; SMN2THRBALOX15 | |
| SCHEMBL12087568 | 0.77 | RAB9A (0.37) | SMN1; SMN2THRBALOX15 | |
| SCHEMBL10305200 | 0.75 | SMN1; SMN2 (0.46) | SMN1; SMN2 | |
| SCHEMBL10549138 | 0.74 | SMN1; SMN2 (0.32) | SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4256911-A | TRIFLUOROMETHYL-CARBOXY ESTERS | HOFFMANN-LA ROCHE INC. (US) | 1981-03-17 | — | — | US | disclosed |
| US-4237276-A | CARDIOVASCULAR AGENTS, INDUCTION OF LABOR, TERMINATION OF PREGNANCY | HOFFMANN-LA ROCHE INC. (US) | 1980-12-02 | — | — | US | disclosed |
| US-4211724-A | ENANTIOMORPHS, INTERMEDIATE AMIDES WITH ASSYMETRIC CARBON ATOM | HOFFMAN-LA ROCHE INC. (US) | 1980-07-08 | — | — | US | disclosed |
| US-4190587-A | PROSTAGLANDINS | HOFFMANN-LA ROCHE INC. (US) | 1980-02-26 | — | — | US | disclosed |
| US-4187381-A | CARDIOVASCULAR AGENTS; OXYTOCICS | HOFFMANN-LA ROCHE INC. (US) | 1980-02-05 | — | — | US | disclosed |
| US-4112225-A | 16-CF3 prostaglandins | HOFFMAN-LA ROCHE INC. (US) | 1978-09-05 | — | — | US | disclosed |