Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 3/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.33 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.33 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.33 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 3/20 | 0.31 |
| ▸ | TSHR | P16473 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 2/20 | 0.30 |
| ▸ | RAB9A | P51151 | 2/20 | 0.30 |
| ▸ | MMP1 | P03956 | 1/20 | 0.30 |
| ▸ | MMP2 | P08253 | 1/20 | 0.30 |
| ▸ | MMP9 | P14780 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10436899 | 0.78 | ALDH1A1 (0.32) | ADRA2AADRA2BADRA2CSLC1A3SLC1A2 | |
| SCHEMBL6439988 | 0.78 | ALDH1A1 (0.35) | ADRA2AADRA2BADRA2CPOLBNPC1 | |
| SCHEMBL4614540 | 0.76 | MMP12 (0.41) | NPC1SMN1; SMN2ALDH1A1HPGDRAB9A | |
| SCHEMBL174237 | 0.75 | — | — | |
| SCHEMBL11290456 | 0.73 | PTPN1 (0.35) | ADRA2AADRA2BADRA2CPOLBNPC1 | |
| SCHEMBL4994884 | 0.72 | HPGD (0.37) | NPC1SMN1; SMN2KMT2AALDH1A1MEN1 | |
| SCHEMBL18906071 | 0.72 | TAAR1 (0.45) | POLBTSHRSMN1; SMN2ALDH1A1L3MBTL1 | |
| SCHEMBL9818348 | 0.71 | TSHR (0.46) | TSHRSMN1; SMN2KMT2AALDH1A1HTT | |
| SCHEMBL10436898 | 0.71 | TAAR1 (0.34) | POLBTSHRSMN1; SMN2ALDH1A1L3MBTL1 | |
| SCHEMBL4484217 | 0.71 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0065295-A1 | Tryptamine derivatives of thienyloxypropanol amines, process for their preparation, pharmaceutical compositions containing them and preparation of the latter | HOECHST AKTIENGESELLSCHAFT (DE) | 1982-11-24 | — | — | EP | disclosed |
| EP-0065295-A1 | Tryptamine derivatives of thienyloxypropanol amines, process for their preparation, pharmaceutical compositions containing them and preparation of the latter | HOECHST AKTIENGESELLSCHAFT (DE) | 1982-11-24 | — | — | EP | disclosed |