Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.42 |
| ▸ | EHMT1 | Q9H9B1 | 1/20 | 0.42 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 5/20 | 0.42 |
| ▸ | RAB9A | P51151 | 5/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1129847 | 0.97 | ALDH1A1 (0.49) | ALDH1A1KMT2AMAPTSMN1; SMN2TDP1 | |
| SCHEMBL1130079 | 0.95 | ALDH1A1 (0.47) | ALDH1A1KMT2AMAPTSMN1; SMN2TDP1 | |
| SCHEMBL1129373 | 0.95 | ALDH1A1 (0.47) | ALDH1A1KMT2AMAPTSMN1; SMN2TDP1 | |
| SCHEMBL422519 | 0.79 | ALDH1A1 (0.54) | ALDH1A1KMT2AMAPTSMN1; SMN2TDP1 | |
| SCHEMBL1743693 | 0.77 | ALDH1A1 (0.53) | ALDH1A1KMT2AMAPTSMN1; SMN2TDP1 | |
| SCHEMBL5046104 | 0.77 | ALDH1A1 (0.53) | ALDH1A1KMT2AMAPTSMN1; SMN2TDP1 | |
| SCHEMBL10974209 | 0.77 | ALDH1A1 (0.56) | ALDH1A1KMT2AMAPTSMN1; SMN2TDP1 | |
| SCHEMBL1129408 | 0.76 | ALDH1A1 (0.50) | ALDH1A1KMT2ANPC1RAB9ALMNA | |
| SCHEMBL15271423 | 0.76 | ALDH1A1 (0.51) | ALDH1A1KMT2AMAPTSMN1; SMN2TDP1 | |
| SCHEMBL15271663 | 0.76 | ALDH1A1 (0.51) | ALDH1A1KMT2AMAPTSMN1; SMN2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3124489-B1 | THIAZOLO-PYRIDINE COMPOUNDS AS HIF MODULATORS | FIBROGEN INC (US) | 2020-07-15 | — | — | EP | disclosed |
| EP-2952256-B1 | METHOD FOR THE PRODUCTION OF CATALYSTS | LANXESS DEUTSCHLAND GMBH (DE) | 2017-05-17 | — | — | EP | disclosed |
| EP-3124489-A1 | THIAZOLO-PYRIDINE COMPOUNDS AS HIF MODULATORS | Fibrogen, Inc. (US) | 2017-02-01 | — | — | EP | disclosed |
| EP-2016078-B1 | PYRROLO- AND THIAZOLO-PYRIDINE COMPOUNDS AS HIF MODULATORS | FIBROGEN INC (US) | 2016-06-15 | — | — | EP | disclosed |
| EP-2952256-A1 | METHOD FOR THE PRODUCTION OF CATALYSTS | LANXESS Deutschland GmbH (DE) | 2015-12-09 | — | — | EP | disclosed |
| EP-2158040-B1 | PREPARATION OF CATALYST FOR BISPHENOLS PRODUCTION | DOW GLOBAL TECHNOLOGIES INC (US) | 2011-02-16 | — | — | EP | disclosed |
| US-7696223-B2 | [(2-bromo-4-hydroxy-1-phenyl-1H-pyrrolo[2,3-c]pyridine-5-carbonyl)-amino]-acetic acid; modulates the stability and/or activity of hypoxia inducible factor (HIF) | FIBROGEN, INC. (US) | 2010-04-13 | — | — | US | disclosed |
| EP-2158040-A1 | PREPARATION OF CATALYST FOR BISPHENOLS PRODUCTION | Dow Global Technologies Inc. (US) | 2010-03-03 | — | — | EP | disclosed |
| EP-2016078-A2 | PYRROLO- AND THIAZOLO-PYRIDINE COMPOUNDS AS HIF MODULATORS | FIBROGEN, INC. (US) | 2009-01-21 | — | — | EP | disclosed |
| WO-2008157025-A1 | PREPARATION OF CATALYST FOR BISPHENOLS PRODUCTION | DOW GLOBAL TECHNOLOGIES INC. (US) | 2008-12-24 | — | — | WO | disclosed |
| US-20080004309-A1 | PYRROLO- AND THIAZOLO-PYRIDINE COMPOUNDS, AND METHODS OF USE THEREOF | FIBROGEN, INC. | 2008-01-03 | — | — | US | disclosed |
| WO-2007115315-A2 | PYRROLO- AND THIAZOLO-PYRIDINE COMPOUNDS AS HIF MODULATORS | FIBROGEN, INC. (US) | 2007-10-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080004309-A1 | PYRROLO- AND THIAZOLO-PYRIDINE COMPOUNDS, AND METHODS OF USE THEREOF | HIF1AN, HIF1A, EGLN2 | ALDH1A1 1047/4885KMT2A 1354/4885MAPT 2965/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.