Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.52 |
| ▸ | ALOX12 | P18054 | 5/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | MITF | O75030 | 1/20 | 0.48 |
| ▸ | ACHE | P22303 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15328268 | 0.82 | SMN1; SMN2 (0.77) | SMN1; SMN2ALDH1A1ALOX12RAB9AMITF | |
| SCHEMBL11314926 | 0.81 | SMN1; SMN2 (0.55) | SMN1; SMN2ALDH1A1ALOX12RAB9AMITF | |
| SCHEMBL11703253 | 0.81 | RAB9A (0.64) | SMN1; SMN2ALDH1A1ALOX12RAB9AMITF | |
| SCHEMBL11312703 | 0.80 | SMN1; SMN2 (0.56) | SMN1; SMN2ALDH1A1ALOX12RAB9AMITF | |
| SCHEMBL2394596 | 0.79 | NPC1 (0.61) | ALDH1A1ALOX12RAB9AKDM4ENPC1 | |
| SCHEMBL11312033 | 0.79 | SMN1; SMN2 (0.55) | SMN1; SMN2ALDH1A1ALOX12RAB9AMITF | |
| SCHEMBL15328351 | 0.78 | SMN1; SMN2 (0.71) | SMN1; SMN2ALDH1A1ALOX12RAB9AMITF | |
| SCHEMBL11313298 | 0.78 | RAB9A (0.63) | SMN1; SMN2ALDH1A1ALOX12RAB9AMITF | |
| SCHEMBL11318847 | 0.77 | HRH2 (0.42) | ALDH1A1KDM4ELMNAMAPT | |
| SCHEMBL15328470 | 0.76 | ALDH1A1 (0.78) | SMN1; SMN2ALDH1A1ALOX12RAB9AMITF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4307101-A | ANTIHISTAMINES AND ANTISECRETORY AGENTS OF THE THIOUREA OR UREA DERIVATIVES 5,6,7,8-TETRAHYDROIMIDAZO(1,5A)PYRIDINE | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1981-12-22 | — | — | US | disclosed |
| US-4293697-A | ANTIHISTAMINES | SMITH, KLINE & FRENCH LABORATORIES LIMITED (GB) | 1981-10-06 | — | — | US | disclosed |
| US-4230865-A | ANTIHISTAMINES | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1980-10-28 | — | — | US | disclosed |
| US-4226874-A | ANTIHISTAMINES, ANTISECRETORY AGENTS, GASTRIC JUICE | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1980-10-07 | — | — | US | disclosed |
| US-4151288-A | ANTHISTAMINES | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1979-04-24 | — | — | US | disclosed |
| US-4137234-A | ANTIHISTAMINES | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1979-01-30 | — | — | US | disclosed |
| US-4018931-A | INHIBITION OF H-2 HISTAMINE RECEPTORS | SMITH KLINE & FRENCH LABORATORIES LIMITED (EN) | 1977-04-19 | — | — | US | disclosed |
| US-3950353-A | HISTAMINE INHIBITORS | SMITH KLINE & FRENCH LABORATORIES LIMITED (EN) | 1976-04-13 | — | — | US | disclosed |