Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SDRD2HTR1BHTR1DHTR1F
The experimentally established mechanism targets of Malic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.39 |
| ▸ | TET2 | Q6N021 | 6/20 | 0.38 |
| ▸ | TET3 | O43151 | 2/20 | 0.38 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.38 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.36 |
| ▸ | KDM4A | O75164 | 2/20 | 0.35 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.35 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | KMO | O15229 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Malic Acid SCHEMBL27655462 | 0.84 | SMN1; SMN2 (0.60) | SMN1; SMN2OR51E2TET2TET3TET1 | |
| Trolamine SCHEMBL5874557 | 0.83 | SMN1; SMN2 (0.65) | SMN1; SMN2MAPTOR51E2TET2TET3 | |
| Malic Acid SCHEMBL5874756 | 0.83 | SMN1; SMN2 (0.79) | SMN1; SMN2MAPTOR51E2TET2TET3 | |
| Malic Acid SCHEMBL5874761 | 0.83 | SMN1; SMN2 (0.79) | SMN1; SMN2MAPTOR51E2TET2TET3 | |
| Dimethylaminoethanol SCHEMBL13730571 | 0.82 | MAPT (0.50) | SMN1; SMN2MAPTOR51E2TET2TET3 | |
| Malic Acid SCHEMBL28317492 | 0.80 | SMN1; SMN2 (0.83) | SMN1; SMN2OR51E2TET2TET3TET1 | |
| Malic Acid SCHEMBL27748793 | 0.80 | SMN1; SMN2 (0.83) | SMN1; SMN2OR51E2TET2TET3TET1 | |
| Malic Acid SCHEMBL19878635 | 0.79 | SMN1; SMN2 (0.54) | SMN1; SMN2TET2TET3TET1KDM4A | |
| Cadaverine Tartrate SCHEMBL989096 | 0.79 | MAPT (0.57) | MAPTOR51E2TDP1L3MBTL1 | |
| Tartaric Acid SCHEMBL30104959 | 0.79 | MAPT (0.57) | MAPTOR51E2TDP1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8784686-B2 | Liquids | INNOVIA FILMS LIMITED (GB) | 2014-07-22 | — | — | US | claimed |
| EP-1805131-B1 | IONIC LIQUIDS COMPRISING NITROGEN CONTAINING CATIONS | INNOVIA FILMS LTD (GB) | 2011-02-16 | — | — | EP | claimed |
| US-20070185330-A1 | Liquids | THE UNIVERSITY OF YORK (GB) | 2007-08-09 | — | — | US | claimed |
| US-9328220-B2 | Liquids | INNOVIA FILMS LIMITED (GB) | 2016-05-03 | — | — | US | disclosed |
| US-8992798-B2 | Liquids | INNOVIA FILMS LIMITED (GB) | 2015-03-31 | — | — | US | disclosed |
| US-8784686-B2 | Liquids | INNOVIA FILMS LIMITED (GB) | 2014-07-22 | — | — | US | disclosed |
| US-20140187684-A1 | LIQUIDS | INNOVIA FILMS LIMITED (GB) | 2014-07-03 | — | — | US | disclosed |
| US-20110257433-A1 | LIQUIDS | THE UNIVERSITY OF YORK (GB) | 2011-10-20 | — | — | US | disclosed |
| EP-2322497-A1 | Ionic liquids comprising nitrogen containing cations | Innovia Films Limited (GB) | 2011-05-18 | — | — | EP | disclosed |
| EP-1805131-B1 | IONIC LIQUIDS COMPRISING NITROGEN CONTAINING CATIONS | INNOVIA FILMS LTD (GB) | 2011-02-16 | — | — | EP | disclosed |
| US-20080221361-A1 | Ionic Liquids | BIONIQS LIMITED (GB) | 2008-09-11 | — | — | US | disclosed |
| US-20070185330-A1 | Liquids | THE UNIVERSITY OF YORK (GB) | 2007-08-09 | — | — | US | disclosed |