Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SDRD2HTR1BHTR1DHTR1F
The experimentally established mechanism targets of Malic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | GPR84 | Q9NQS5 | 7/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.39 |
| ▸ | TET2 | Q6N021 | 6/20 | 0.38 |
| ▸ | TET3 | O43151 | 2/20 | 0.38 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.38 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.36 |
| ▸ | KDM4A | O75164 | 2/20 | 0.35 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.35 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.35 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Malic Acid SCHEMBL5875327 | 0.86 | SMN1; SMN2 (0.62) | SMN1; SMN2GPR84FFAR1TET2TET3 | |
| Malic Acid SCHEMBL5875321 | 0.86 | SMN1; SMN2 (0.62) | SMN1; SMN2GPR84FFAR1TET2TET3 | |
| Malic Acid SCHEMBL11772086 | 0.85 | DNM1 (0.52) | SMN1; SMN2GPR84FFAR1KDM4AKDM4C | |
| Malic Acid SCHEMBL11772074 | 0.85 | DNM1 (0.52) | SMN1; SMN2GPR84FFAR1KDM4AKDM4C | |
| Malic Acid SCHEMBL1131217 | 0.84 | SMN1; SMN2 (0.60) | SMN1; SMN2TET2TET3TET1SLC22A6 | |
| Malic Acid SCHEMBL20394029 | 0.83 | SMN1; SMN2 (0.79) | SMN1; SMN2GPR84FFAR1TET2TET3 | |
| Malic Acid SCHEMBL5874761 | 0.83 | SMN1; SMN2 (0.79) | SMN1; SMN2GPR84TET2TET3TET1 | |
| Malic Acid SCHEMBL5874756 | 0.83 | SMN1; SMN2 (0.79) | SMN1; SMN2GPR84TET2TET3TET1 | |
| Malic Acid SCHEMBL28768725 | 0.80 | SMN1; SMN2 (0.83) | SMN1; SMN2GPR84FFAR1TET2TET3 | |
| Malic Acid SCHEMBL19878635 | 0.79 | SMN1; SMN2 (0.54) | SMN1; SMN2TET2TET3TET1KDM4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104188833-A | AQUEOUS COMPOSITION SUITABLE AS SHAMPOO | RHODIA OPERATIONS | 2014-12-10 | — | — | CN | disclosed |
| CN-1853600-B | Hair cleansing composition | KAO CORP | 2013-06-19 | — | — | CN | disclosed |
| CN-1823714-B | Aqueous hair cleansing composition | KAO CORPORATION (JP) | 2011-12-21 | — | — | CN | disclosed |
| CN-102271650-A | Aqueous composition suitable as a shampoo | — | 2011-12-07 | — | — | CN | disclosed |
| CN-1853600-A | Hair cleansing composition | KAO CORP (JP) | 2006-11-01 | — | — | CN | disclosed |
| CN-1823714-A | Aqueous hair cleansing composition | KAO CORP (JP) | 2006-08-30 | — | — | CN | disclosed |
| CN-1823713-A | Aqueous hair cleansing composition | KAO CORP (JP) | 2006-08-30 | — | — | CN | disclosed |