Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.57 |
| ▸ | RAB9A | P51151 | 3/20 | 0.57 |
| ▸ | TP53 | P04637 | 2/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | FABP3 | P05413 | 1/20 | 0.47 |
| ▸ | FABP4 | P15090 | 1/20 | 0.47 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | DHFR | P00374 | 4/20 | 0.45 |
| ▸ | HEXA | P06865 | 1/20 | 0.45 |
| ▸ | HEXB | P07686 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5509874 | 0.83 | KDM4E (0.55) | KDM4ERAB9ATP53HSD17B10KMT2A | |
| SCHEMBL31556277 | 0.75 | DHFR (0.47) | TP53KMT2AALDH1A1SMN1; SMN2DHFR | |
| SCHEMBL11494053 | 0.74 | KDM4E (0.73) | KDM4ERAB9ATP53HSD17B10KMT2A | |
| SCHEMBL27633592 | 0.74 | KDM4E (0.54) | KDM4ERAB9ATP53HSD17B10KMT2A | |
| SCHEMBL5521948 | 0.72 | KDM4E (0.56) | KDM4ERAB9ATP53HSD17B10KMT2A | |
| SCHEMBL5659586 | 0.72 | GABRP (0.41) | KDM4ERAB9ATP53HSD17B10KMT2A | |
| SCHEMBL11908452 | 0.72 | GABRP (0.41) | KDM4ERAB9ATP53HSD17B10KMT2A | |
| SCHEMBL5961069 | 0.72 | FABP3 (0.49) | KDM4ERAB9ATP53HSD17B10KMT2A | |
| SCHEMBL3258197 | 0.72 | TSHR (0.80) | KDM4ERAB9ATP53HSD17B10KMT2A | |
| SCHEMBL10377332 | 0.71 | CFTR (0.47) | RAB9ATP53KMT2ANPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4301281-A | 7,8-Dihydro-2,5,8-trisubstituted-7-oxo-pyrido[2,3-d]-pyrimidine-6-carboxylic acid amides | AMERICAN HOME PRODUCTS CORPORATION (US) | 1981-11-17 | — | — | US | disclosed |