Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 13/20 | 0.56 |
| ▸ | ACE2 | Q9BYF1 | 4/20 | 0.54 |
| ▸ | LTA4H | P09960 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11313236 | 1.00 | ACE (0.56) | ACEACE2LTA4HLMNA | |
| SCHEMBL7383518 | 0.89 | ACE (0.62) | ACEACE2LTA4HLMNA | |
| SCHEMBL11268587 | 0.89 | ACE (0.62) | ACEACE2LTA4HLMNA | |
| Probestin SCHEMBL27581929 | 0.85 | ACE (0.50) | ACEACE2LTA4H | |
| Probestin SCHEMBL27581925 | 0.85 | ACE (0.50) | ACEACE2LTA4H | |
| Probestin SCHEMBL27581922 | 0.85 | ACE (0.50) | ACEACE2LTA4H | |
| Probestin SCHEMBL12609366 | 0.85 | ACE (0.50) | ACEACE2LTA4H | |
| SCHEMBL10656412 | 0.85 | ACE (0.58) | ACEACE2LTA4HLMNA | |
| SCHEMBL9068758 | 0.84 | ACE (0.60) | ACEACE2LTA4HLMNA | |
| SCHEMBL10768815 | 0.84 | ACE (0.59) | ACEACE2LTA4HLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4293481-A | AND USEFUL AS HYPOTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1981-10-06 | — | — | US | claimed |
| US-4293481-A | AND USEFUL AS HYPOTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1981-10-06 | — | — | US | disclosed |