Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5400575 | 0.79 | CYP19A1 (0.37) | CYP19A1 | |
| SCHEMBL2659458 | 0.75 | CYP19A1 (0.33) | CYP19A1 | |
| SCHEMBL8890451 | 0.74 | — | — | |
| SCHEMBL6616364 | 0.74 | ALDH1A1 (0.34) | — | |
| SCHEMBL29959382 | 0.68 | THRB (0.31) | — | |
| SCHEMBL7268446 | 0.68 | CYP19A1 (0.38) | CYP19A1 | |
| SCHEMBL12369613 | 0.67 | CYP19A1 (0.41) | CYP19A1 | |
| SCHEMBL6999923 | 0.67 | CYP19A1 (0.38) | CYP19A1 | |
| SCHEMBL20397431 | 0.66 | — | — | |
| SCHEMBL14214803 | 0.66 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2638021-A2 | METALLOENZYME INHIBITOR COMPOUNDS | Viamet Pharmaceuticals, Inc. (US) | 2013-09-18 | — | — | EP | disclosed |
| WO-2012064943-A2 | METALLOENZYME INHIBITOR COMPOUNDS | VIAMET PHARMACEUTICALS, INC. (US) | 2012-05-18 | — | — | WO | disclosed |
| EP-1379498-B1 | SULPHONES WHICH MODULATE THE ACTION OF GAMMA SECRETASE | MERCK SHARP & DOHME (GB) | 2011-02-16 | — | — | EP | disclosed |
| US-7598386-B2 | Sulphones which modulate the action of gamma-secretase | MERCK SHARP & DOHME LIMITED (GB) | 2009-10-06 | — | — | US | disclosed |
| US-7595344-B2 | Sulphones which modulate the action of gamma secretase | MERCK SHARP & DOHME LIMITED (GB) | 2009-09-29 | — | — | US | disclosed |
| US-20090131419-A1 | Sulphones which modulate the action of gamma secretase | MERCK SHARP & DOHME (UK) LIMITED (GB) | 2009-05-21 | — | — | US | disclosed |
| US-20080045533-A1 | Novel cyclohexyl sulphones | CHURCHER IAN | 2008-02-21 | — | — | US | disclosed |
| US-7304094-B2 | Alzheimer's disease, modulate the processing of amyloid precursor protein by gamma-secretase | MERCK SHARP + DOHME | 2007-12-04 | — | — | US | disclosed |
| US-20070213329-A1 | Sulphones which modulate the action of gammasecretase | MERCK SHARP & DOHME (UK) LIMITED (GB) | 2007-09-13 | — | — | US | disclosed |
| US-20060041020-A1 | Novel cyclohexyl sulphones | MERCK SHARP & DOHME (UK) LIMITED (GB) | 2006-02-23 | — | — | US | disclosed |
| US-6984663-B2 | Treatment or prevention of Alzheimer's disease | MERCK SHARP & DOHME LIMITED (GB) | 2006-01-10 | — | — | US | disclosed |
| US-20040116404-A1 | Sulphones which modulate the action of gamma secretase | MERCK SHARP & DOHME LTD. (GB) | 2004-06-17 | — | — | US | disclosed |
| EP-1379498-A1 | SULPHONES WHICH MODULATE THE ACTION OF GAMMA SECRETASE | MERCK SHARP & DOHME LTD. (GB) | 2004-01-14 | — | — | EP | disclosed |
| US-20030114496-A1 | Novel cyclohexyl sulphones | MERCK SHARP & DOHME (UK) LIMITED (GB) | 2003-06-19 | — | — | US | disclosed |
| WO-2002081435-A1 | SULPHONES WHICH MODULATE THE ACTION OF GAMMA SECRETASE | MERCK SHARP & DOHME LIMITED (GB) | 2002-10-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090131419-A1 | Sulphones which modulate the action of gamma secretase | BACE1, BACE2, PSEN1 | CYP19A1 1506/4885 |
| US-20080045533-A1 | Novel cyclohexyl sulphones | BACE1, APP, PSEN1 | CYP19A1 1650/4885 |
| US-20060041020-A1 | Novel cyclohexyl sulphones | BACE1, APP, PSEN1 | CYP19A1 1650/4885 |
| US-20070213329-A1 | Sulphones which modulate the action of gammasecretase | BACE1, PSEN1, BACE2 | CYP19A1 510/4885 |
| US-20030114496-A1 | Novel cyclohexyl sulphones | BACE1, APP, PSEN1 | CYP19A1 1485/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.