SCHEMBL11315744

SCHEMBL11315744

COc1ccc(-c2nn3ccccc3c2C=O)cc1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 3/20 0.51
RAB9A P51151 3/20 0.51
KDM4E B2RXH2 3/20 0.51
ALDH1A1 P00352 3/20 0.51
SMN1; SMN2 Q16637 2/20 0.51
KMT2A Q03164 3/20 0.48
MEN1 O00255 2/20 0.48
NLRP3 Q96P20 1/20 0.48
RXFP1 Q9HBX9 1/20 0.45
CYP1A2 P05177 1/20 0.44
CYP3A4 P08684 1/20 0.44
HPGD P15428 1/20 0.44
CYP2C19 P33261 1/20 0.44
HTT P42858 1/20 0.44
ADORA1 P30542 4/20 0.42
ADORA3 P0DMS8 3/20 0.42
GABRP O00591 1/20 0.42
GABRD O14764 1/20 0.42
GABRA1 P14867 1/20 0.42
GABRB1 P18505 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8811759 0.84 ADORA2A (0.45) ALDH1A1ADORA1ADORA3ADORA2AEGFR
SCHEMBL9959559 0.81 KMT2A (0.40) NPC1RAB9AKDM4EALDH1A1SMN1; SMN2
SCHEMBL5219219 0.81 GABRP (0.44) NPC1RAB9AKDM4EALDH1A1SMN1; SMN2
SCHEMBL9197465 0.80 MAPK14 (0.55) KDM4EALDH1A1SMN1; SMN2KMT2AMEN1
SCHEMBL6105207 0.76 KMT2A (0.43) NPC1RAB9AKDM4EALDH1A1SMN1; SMN2
SCHEMBL3207452 0.74 ALDH1A1 (0.57) NPC1RAB9AKDM4EALDH1A1SMN1; SMN2
SCHEMBL30997285 0.74 SMN1; SMN2 (0.44) ALDH1A1SMN1; SMN2CYP1A2CYP3A4CYP2C19
SCHEMBL9201911 0.73 PARP1 (0.38) KDM4EALDH1A1CYP1A2CYP2C19ADORA1
SCHEMBL13610008 0.72 EGFR (0.46) NPC1RAB9AKDM4EALDH1A1SMN1; SMN2
SCHEMBL8193833 0.72 ADORA1 (0.52) NPC1RAB9AKDM4EALDH1A1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4259439-A DIMETHINECYANINE DYE SENSITIZER MITSUBISHI PAPER MILLS, LTD. (JP) 1981-03-31 US disclosed