Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 2/20 | 0.62 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.62 |
| ▸ | PDE4A | P27815 | 1/20 | 0.62 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.62 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.62 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.62 |
| ▸ | BRD4 | O60885 | 4/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.54 |
| ▸ | HPGD | P15428 | 3/20 | 0.54 |
| ▸ | GAA | P10253 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | GALR3 | O60755 | 1/20 | 0.54 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.50 |
| ▸ | CCNC | P24863 | 1/20 | 0.47 |
| ▸ | CDK8 | P49336 | 1/20 | 0.47 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.44 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | JAK1 | P23458 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7276070 | 0.87 | PDE3B (0.61) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL11002239 | 0.86 | PDE3B (0.49) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10993067 | 0.85 | PARP1 (0.46) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10704473 | 0.85 | CCNC (0.67) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL11078693 | 0.84 | MKNK1 (0.56) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL28942178 | 0.83 | GAA (0.41) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10995118 | 0.82 | SMN1; SMN2 (0.48) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10993050 | 0.82 | PARP1 (0.51) | KDM4EALDH1A1HSD17B10JAK2IKBKB | |
| SCHEMBL10995836 | 0.81 | GAA (0.41) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10992715 | 0.80 | CDC7 (0.47) | PDE3BPDE3APDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1981002575-A1 | DERIVATIVES OF 2(1H)-PYRIDINONE,THEIR PREPARATION AND PHARMACEUTICAL COMPOSITION CONTAINING THEM | SANDOZ AG (CH) | 1981-09-17 | — | — | WO | disclosed |