Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNC | P24863 | 3/20 | 0.67 |
| ▸ | CDK8 | P49336 | 3/20 | 0.67 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.64 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.64 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.64 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.64 |
| ▸ | CDC7 | O00311 | 9/20 | 0.58 |
| ▸ | PDE4A | P27815 | 2/20 | 0.56 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.56 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.56 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | PDE5A | O76074 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | BLM | P54132 | 1/20 | 0.56 |
| ▸ | BTK | Q06187 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11234900 | 0.87 | PDE3B (0.61) | CCNCCDK8PDE3BPDE3AAURKB | |
| SCHEMBL11315754 | 0.85 | PDE3B (0.62) | CCNCCDK8PDE3BPDE3AAURKB | |
| SCHEMBL11230846 | 0.85 | PDE3B (0.59) | CCNCCDK8PDE3BPDE3AAURKB | |
| SCHEMBL11078693 | 0.85 | MKNK1 (0.56) | CCNCCDK8PDE3BPDE3AAURKB | |
| SCHEMBL11084198 | 0.85 | CCNC (0.53) | CCNCCDK8PDE3BPDE3AAURKB | |
| SCHEMBL10965436 | 0.84 | CDC7 (0.51) | CCNCCDK8PDE3BPDE3AAURKB | |
| SCHEMBL11002239 | 0.84 | PDE3B (0.49) | CCNCCDK8PDE3BPDE3AAURKB | |
| SCHEMBL9670148 | 0.83 | CDC7 (0.54) | CCNCCDK8PDE3BPDE3AAURKB | |
| SCHEMBL11232569 | 0.83 | CYP46A1 (0.58) | CCNCCDK8PDE3BPDE3AAURKB | |
| SCHEMBL10966927 | 0.83 | CDK5 (0.64) | CCNCCDK8CDC7CDK5CDK5R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4313951-A | 3-Substituted-6-(lower-alkyl)-5-(pyridinyl)-2(1H)-pyridinones, their cardiotonic use and intermediates therefor | STERLING DRUG INC. (US) | 1982-02-02 | — | — | US | claimed |
| CN-116098861-A | Milrinone injection and preparation method thereof | 河南省肿瘤医院 | 2023-05-12 | — | — | CN | disclosed |
| CN-104173343-A | Milrinone compound and pharmaceutical composition containing milrinone compound | LANGTIAN PHARMACEUTICAL HUBEI CO LTD | 2014-12-03 | — | — | CN | disclosed |
| EP-0127756-B1 | PROCESS FOR THE PREPARATION OF 5-PYRIDYL-PYRIDINE-2(1H)-ONES | FABRICA DE PRODUCTOS QUIMICOS Y FARMACEUTICOS ABELLO, S.A. (ES) | 1988-10-26 | — | — | EP | disclosed |
| US-4563528-A | Process for preparing 5 pyridyl pyridine-2 (1H)-ones | FABRICA DE PRODUCTOS QUIMICOS Y FARMACEUTICOS ABELLO, S.A. (ES) | 1986-01-07 | — | — | US | disclosed |
| EP-0127756-A1 | Process for the preparation of 5-pyridyl-pyridine-2(1H)-ones | FABRICA DE PRODUCTOS QUIMICOS Y FARMACEUTICOS ABELLO, S.A. (ES) | 1984-12-12 | — | — | EP | disclosed |
| US-4469871-A | Process for preparing 2-(lower-alkoxy)-1-(pyridinyl) ethenyl lower-alkyl ketones | STERLING DRUG INC. (US) | 1984-09-04 | — | — | US | disclosed |
| EP-0095152-A1 | A process for preparing nicotinonitriles and intermediates used therein | STERLING DRUG INC. (US) | 1983-11-30 | — | — | EP | disclosed |
| US-4417054-A | 2-(Lower-alkoxy)-1-(pyridinyl)ethenyl lower-alkyl ketones | STERLING DRUG INC. (US) | 1983-11-22 | — | — | US | disclosed |
| US-4365065-A | 1-(Pyridinyl)-2-(dimethylamino)ethenyl lower-alkyl ketones | STERLING DRUG INC. (US) | 1982-12-21 | — | — | US | disclosed |
| US-4313951-A | 3-Substituted-6-(lower-alkyl)-5-(pyridinyl)-2(1H)-pyridinones, their cardiotonic use and intermediates therefor | STERLING DRUG INC. (US) | 1982-02-02 | — | — | US | disclosed |