Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Carbenicillin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.88 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.78 |
| ▸ | RECQL | P46063 | 4/20 | 0.78 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.78 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.78 |
| ▸ | POLB | P06746 | 3/20 | 0.78 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.78 |
| ▸ | GLA | P06280 | 1/20 | 0.78 |
| ▸ | BLM | P54132 | 1/20 | 0.78 |
| ▸ | HPGD | P15428 | 3/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.74 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.68 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.63 |
| ▸ | MEN1 | O00255 | 1/20 | 0.63 |
| ▸ | TEK | Q02763 | 1/20 | 0.63 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.63 |
| ▸ | FPR1 | P21462 | 1/20 | 0.62 |
| ▸ | TSHR | P16473 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Carbenicillin SCHEMBL11317057 | 1.00 | LMNA (0.88) | LMNAKDM4ERECQLHSD17B10CYP3A4 | |
| Carbenicillin SCHEMBL10811380 | 1.00 | LMNA (0.88) | LMNAKDM4ERECQLHSD17B10CYP3A4 | |
| Carbenicillin SCHEMBL8974021 | 0.94 | LMNA (0.89) | LMNAKDM4ERECQLHSD17B10CYP3A4 | |
| Carbenicillin SCHEMBL11311430 | 0.94 | LMNA (1.00) | LMNAKDM4ERECQLHSD17B10CYP3A4 | |
| Carbenicillin SCHEMBL54797 | 0.94 | LMNA (1.00) | LMNAKDM4ERECQLHSD17B10CYP3A4 | |
| Carbenicillin SCHEMBL11310973 | 0.90 | PTGS1 (0.77) | LMNAKDM4ERECQLHSD17B10CYP3A4 | |
| Carbenicillin SCHEMBL8402462 | 0.90 | PTGS1 (0.77) | LMNAKDM4ERECQLHSD17B10CYP3A4 | |
| Carbenicillin SCHEMBL320405 | 0.90 | PTGS1 (0.77) | LMNAKDM4ERECQLHSD17B10CYP3A4 | |
| Carbenicillin SCHEMBL11604897 | 0.90 | PTGS1 (0.77) | LMNAKDM4ERECQLHSD17B10CYP3A4 | |
| Carbenicillin SCHEMBL11310979 | 0.90 | PTGS1 (0.77) | LMNAKDM4ERECQLHSD17B10CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4304717-A | Process for the preparation of reactive penicillanic acid and cephalosporanic acid derivatives | CHINOIN GYOGYSZER ES VEGYESZETI TERMEKEK GYARA RT (HU) | 1981-12-08 | — | — | US | disclosed |
| US-4171303-A | Process for the preparation of reactive penicillanic acid and cephalosporanic acid derivatives | CHINOIN GYOGYSZER ES VEGYESZETI TERMEKEK GYARA RT. (HU) | 1979-10-16 | — | — | US | disclosed |