Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Monoethanolamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | G6PD | P11413 | 1/20 | 0.45 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.45 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | HSPA5 | P11021 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 2/20 | 0.42 |
| ▸ | HTR2C | P28335 | 2/20 | 0.42 |
| ▸ | HTR2B | P41595 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29354255 | 0.88 | ALDH1A1 (0.56) | TAAR1KDM4EMEN1ALDH1A1KMT2A | |
| SCHEMBL116610 | 0.88 | ALDH1A1 (0.56) | TAAR1KDM4EMEN1ALDH1A1KMT2A | |
| Hydrochloric Acid SCHEMBL27583168 | 0.86 | ALDH1A1 (0.54) | TAAR1KDM4EMEN1ALDH1A1KMT2A | |
| SCHEMBL28611072 | 0.86 | ALDH1A1 (0.54) | TAAR1KDM4EMEN1ALDH1A1KMT2A | |
| Hydrochloric Acid SCHEMBL6915484 | 0.86 | ALDH1A1 (0.54) | TAAR1KDM4EMEN1ALDH1A1KMT2A | |
| Trientine SCHEMBL27851402 | 0.83 | CA12 (0.49) | TAAR1KDM4EMEN1ALDH1A1KMT2A | |
| Boric Acid SCHEMBL4657394 | 0.82 | KDM4E (0.50) | TAAR1KDM4EMEN1ALDH1A1KMT2A | |
| Questiomycin B SCHEMBL16239659 | 0.81 | SLC6A4 (0.57) | KDM4EMEN1ALDH1A1KMT2APOLB | |
| SCHEMBL6833269 | 0.81 | KDM4E (0.45) | TAAR1KDM4EMEN1ALDH1A1KMT2A | |
| SCHEMBL27844999 | 0.79 | ALDH1A1 (0.65) | TAAR1KDM4EMEN1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4256799-A | A RIGID FOAM CORE OF A URETHANE-MODIFIED POLYISOCYANURATE; CONSTRUCTION MATERIALS; INSULATION; LOW DENSITY; ASBESTOS, FOILS, AND GLASS FIBER LAYERS | BRIDGESTONE TIRE CO., LTD. (JP) | 1981-03-17 | — | — | US | disclosed |