Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 7/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | SPHK1 | Q9NYA1 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.34 |
| ▸ | TNF | P01375 | 1/20 | 0.32 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.32 |
| ▸ | PTAFR | P25105 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11318242 | 0.83 | GBA1 (0.46) | GBA1ALDH1A1TDP1SPHK1SMN1; SMN2 | |
| SCHEMBL10483645 | 0.81 | ALDH1A1 (0.46) | GBA1ALDH1A1TDP1SPHK1SMN1; SMN2 | |
| SCHEMBL11322928 | 0.79 | GBA1 (0.46) | GBA1ALDH1A1TDP1SPHK1SPHK2 | |
| SCHEMBL18118482 | 0.78 | ALDH1A1 (0.48) | GBA1ALDH1A1TDP1SPHK1SMN1; SMN2 | |
| SCHEMBL11890588 | 0.76 | ALDH1A1 (0.53) | GBA1ALDH1A1TDP1SPHK1SMN1; SMN2 | |
| SCHEMBL17817171 | 0.75 | ALDH1A1 (0.46) | GBA1ALDH1A1TDP1SPHK1SMN1; SMN2 | |
| SCHEMBL17833005 | 0.75 | ALDH1A1 (0.46) | GBA1ALDH1A1TDP1SPHK1SMN1; SMN2 | |
| SCHEMBL7594906 | 0.74 | ALDH1A1 (0.36) | GBA1ALDH1A1TDP1SMN1; SMN2TNF | |
| SCHEMBL7594902 | 0.74 | ALDH1A1 (0.36) | GBA1ALDH1A1TDP1SMN1; SMN2TNF | |
| SCHEMBL11981957 | 0.74 | SMN1; SMN2 (0.43) | GBA1ALDH1A1TDP1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3202760-B1 | PEGYLATED LIPIDS AND THEIR USE FOR DRUG DELIVERY | ALNYLAM PHARMACEUTICALS INC (US) | 2019-08-21 | — | — | EP | disclosed |
| US-9999673-B2 | PEGylated lipids and their use for drug delivery | ALNYLAM PHARMACEUTICALS, INC. (US) | 2018-06-19 | — | — | US | disclosed |
| EP-3202760-A1 | PEGYLATED LIPIDS AND THEIR USE FOR DRUG DELIVERY | Alnylam Pharmaceuticals, Inc. (US) | 2017-08-09 | — | — | EP | disclosed |
| EP-2663548-B1 | PEGYLATED LIPIDS AND THEIR USE FOR DRUG DELIVERY | ALNYLAM PHARMACEUTICALS INC (US) | 2017-04-05 | — | — | EP | disclosed |
| EP-2663548-A1 | PEGYLATED LIPIDS AND THEIR USE FOR DRUG DELIVERY | Alnylam Pharmaceuticals, Inc. (US) | 2013-11-20 | — | — | EP | disclosed |
| WO-2012099755-A1 | PEGYLATED LIPIDS AND THEIR USE FOR DRUG DELIVERY | ALNYLAM PHARMACEUTICALS, INC. (US) | 2012-07-26 | — | — | WO | disclosed |