Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRA | P16234 | 7/20 | 0.54 |
| ▸ | KDR | P35968 | 7/20 | 0.54 |
| ▸ | AXL | P30530 | 3/20 | 0.50 |
| ▸ | MET | P08581 | 2/20 | 0.50 |
| ▸ | MERTK | Q12866 | 1/20 | 0.50 |
| ▸ | SRC | P12931 | 4/20 | 0.46 |
| ▸ | TGFBR1 | P36897 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21198916 | 0.88 | KDR (0.52) | PDGFRAKDRAXLMETMERTK | |
| SCHEMBL1132613 | 0.88 | KDR (0.54) | PDGFRAKDRAXLMETMERTK | |
| SCHEMBL1895689 | 0.86 | KDR (0.71) | PDGFRAKDRAXLMETMERTK | |
| SCHEMBL1132608 | 0.84 | AXL (0.53) | PDGFRAKDRAXLMETMERTK | |
| SCHEMBL21198888 | 0.83 | PDGFRA (0.55) | PDGFRAKDRAXLMETMERTK | |
| SCHEMBL19957375 | 0.82 | KDR (0.53) | PDGFRAKDRAXLMETSRC | |
| SCHEMBL1893379 | 0.82 | KDR (0.53) | PDGFRAKDRAXLMETTDP1 | |
| SCHEMBL21198895 | 0.80 | PDGFRA (0.51) | PDGFRAKDRAXLMETMERTK | |
| SCHEMBL1133096 | 0.79 | AXL (0.59) | PDGFRAKDRAXLMETMERTK | |
| SCHEMBL1133098 | 0.79 | AXL (0.59) | PDGFRAKDRAXLMETMERTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2287155-B1 | ACYLTHIOUREA COMPOUND OR SALT THEREOF, AND USE THEREOF | TAIHO PHARMACEUTICAL CO LTD (JP) | 2013-07-17 | — | — | EP | disclosed |
| US-8304427-B2 | Acylthiourea compound or salt thereof, and use thereof | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 2012-11-06 | — | — | US | disclosed |
| EP-2287155-A1 | ACYLTHIOUREA COMPOUND OR SALT THEREOF, AND USE OF THE COMPOUND OR THE SALT | Taiho Pharmaceutical Co., Ltd. (JP) | 2011-02-23 | — | — | EP | disclosed |
| US-20110034439-A1 | ACYLTHIOUREA COMPOUND OR SALT THEREOF, AND USE THEREOF | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 2011-02-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110034439-A1 | ACYLTHIOUREA COMPOUND OR SALT THEREOF, AND USE THEREOF | MET, HGF, STAT6 | PDGFRA 201/4885KDR 296/4885AXL 568/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.