SCHEMBL11322664

SCHEMBL11322664

O=[N+]([O-])c1cccc(CS(=O)(=O)c2nc3ccc(Cl)cc3[n+]([O-])n2)c1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TXNRD1 Q16881 1/20 0.42
CFTR P13569 2/20 0.40
TSHR P16473 1/20 0.40
ALDH1A1 P00352 3/20 0.39
TDP1 Q9NUW8 1/20 0.39
CCR2 P41597 2/20 0.39
HTT P42858 1/20 0.39
IRAK4 Q9NWZ3 1/20 0.38
FBP1 P09467 1/20 0.38
NPBWR1 P48145 4/20 0.38
MAPT P10636 2/20 0.37
MAPK1 P28482 2/20 0.37
KDM4E B2RXH2 1/20 0.37
LMNA P02545 1/20 0.37
POLB P06746 1/20 0.37
SMN1; SMN2 Q16637 1/20 0.37
HPGD P15428 1/20 0.37
CYP1A2 P05177 1/20 0.36
CYP3A4 P08684 1/20 0.36
CYP2D6 P10635 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11326751 0.82 MEN1 (0.40) TXNRD1ALDH1A1MAPTMAPK1KDM4E
SCHEMBL11319321 0.77 NPBWR1 (0.42) ALDH1A1TDP1HTTNPBWR1MAPT
SCHEMBL11317440 0.76 CYP1A2 (0.35) ALDH1A1HTTKDM4EPOLBCYP1A2
SCHEMBL11155872 0.71 SCD (0.36) ALDH1A1CCR2HTTNPBWR1MAPT
SCHEMBL11314440 0.70 ALDH1A1 (0.40) TXNRD1TSHRALDH1A1TDP1HTT
SCHEMBL11319336 0.70 ALDH1A1 (0.42) ALDH1A1TDP1HTTMAPK1KDM4E
SCHEMBL496751 0.68 TSHR (0.61) TSHRALDH1A1TDP1HTTMAPK1
SCHEMBL6680261 0.67 KMT2A (0.48) TXNRD1TSHRALDH1A1TDP1HTT
SCHEMBL11326374 0.66 HPGD (0.40) ALDH1A1FBP1KDM4EPOLBHPGD
SCHEMBL8870409 0.66 TSHR (0.59) TSHRALDH1A1TDP1HTTMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4289771-A BACTERICIDES, FUNGICIDES BAYER AKTIENGESELLSCHAFT (DE) 1981-09-15 US disclosed