Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 6/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.83 |
| ▸ | MEN1 | O00255 | 5/20 | 0.83 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.83 |
| ▸ | CTDSP1 | Q9GZU7 | 2/20 | 0.83 |
| ▸ | NPC1 | O15118 | 3/20 | 0.78 |
| ▸ | RAB9A | P51151 | 3/20 | 0.78 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.75 |
| ▸ | HTT | P42858 | 1/20 | 0.73 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.72 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.72 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.71 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.70 |
| ▸ | MAPT | P10636 | 2/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.69 |
| ▸ | LMNA | P02545 | 3/20 | 0.69 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.69 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.69 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18103163 | 0.94 | NPC1 (0.88) | POLBKDM4EKMT2AMEN1TDP1 | |
| SCHEMBL14715824 | 0.94 | NPC1 (0.88) | POLBKDM4EKMT2AMEN1TDP1 | |
| SCHEMBL26953087 | 0.91 | PTPN1 (0.88) | POLBKDM4EKMT2AMEN1TDP1 | |
| SCHEMBL126415 | 0.91 | PTPN1 (0.87) | POLBKDM4EKMT2AMEN1NPC1 | |
| SCHEMBL11688443 | 0.90 | DEGS1 (0.83) | POLBKDM4EKMT2AMEN1TDP1 | |
| SCHEMBL14715847 | 0.89 | PTPN1 (0.84) | POLBKDM4EKMT2AMEN1TDP1 | |
| SCHEMBL5344166 | 0.88 | NPC1 (1.00) | POLBKDM4EKMT2AMEN1TDP1 | |
| SCHEMBL8768933 | 0.88 | NPC1 (1.00) | POLBKDM4EKMT2AMEN1TDP1 | |
| SCHEMBL31432724 | 0.88 | NPC1 (1.00) | POLBKDM4EKMT2AMEN1TDP1 | |
| SCHEMBL679222 | 0.88 | DEGS1 (0.79) | POLBKDM4EKMT2AMEN1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4306930-A | INCORPORATING A HYDRAZIDE OR DIHYDRAZIDE AND THEN VULCANIZING IN CONTACT WITH A METAL | CIBA-GEIGY CORPORATION (US) | 1981-12-22 | — | — | US | disclosed |
| US-4077948-A | N-SALICYLIDENE-N*-SALICYLHYDRAZIDES | CIBA-GEIGY CORPORATION (US) | 1978-03-07 | — | — | US | disclosed |
| US-3994987-A | Metal deactivators as adhesion promotors for vulcanizable elastomers to metals | CIBA-GEIGY CORPORATION (US) | 1976-11-30 | — | — | US | disclosed |