Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 1.00 |
| ▸ | RAB9A | P51151 | 4/20 | 1.00 |
| ▸ | MEN1 | O00255 | 3/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 3/20 | 1.00 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.89 |
| ▸ | POLB | P06746 | 3/20 | 0.78 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.78 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.75 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.72 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.72 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.71 |
| ▸ | MAPT | P10636 | 1/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.69 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.69 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.66 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.66 |
| ▸ | HPGD | P15428 | 1/20 | 0.66 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.66 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8768933 | 1.00 | NPC1 (1.00) | NPC1RAB9AMEN1KMT2AFFAR1 | |
| SCHEMBL31432724 | 1.00 | NPC1 (1.00) | NPC1RAB9AMEN1KMT2AFFAR1 | |
| SCHEMBL8910428 | 0.96 | NPC1 (0.92) | NPC1RAB9AMEN1KMT2AFFAR1 | |
| SCHEMBL18103163 | 0.94 | NPC1 (0.88) | NPC1RAB9AMEN1KMT2AFFAR1 | |
| SCHEMBL14715824 | 0.94 | NPC1 (0.88) | NPC1RAB9AMEN1KMT2AFFAR1 | |
| SCHEMBL14484095 | 0.93 | MEN1 (0.86) | NPC1RAB9AMEN1KMT2AFFAR1 | |
| SCHEMBL26953087 | 0.91 | PTPN1 (0.88) | NPC1RAB9AMEN1KMT2AFFAR1 | |
| SCHEMBL126415 | 0.91 | PTPN1 (0.87) | NPC1RAB9AMEN1KMT2AFFAR1 | |
| SCHEMBL11936816 | 0.91 | RAB9A (0.86) | NPC1RAB9AMEN1KMT2AFFAR1 | |
| SCHEMBL14715847 | 0.89 | PTPN1 (0.84) | NPC1RAB9AMEN1KMT2AFFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7230020-B2 | 11β-hydroxysteroid dehydrogenase inhibitors | STERIX LIMITED (GB) | 2007-06-12 | — | — | US | disclosed |
| EP-1675844-A1 | PHENYL CARBOXAMIDE AND SULFONAMIDE DERIVATIVES FOR USE AS 11-BETA-HYDROXYSTEROID DEHYDROGENASE | Sterix Limited (GB) | 2006-07-05 | — | — | EP | disclosed |
| US-20050227987-A1 | 11beta-hydroxysteroid dehydrogenase inhibitors | STERIX LIMITED (GB) | 2005-10-13 | — | — | US | disclosed |
| WO-2005042513-A1 | PHENYL CARBOXAMIDE AND SULFONAMIDE DERIVATIVES FOR USE AS 11-BETA-HYDROXYSTEROID DEHYDROGENASE | STERIX LIMITED (GB) | 2005-05-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050227987-A1 | 11beta-hydroxysteroid dehydrogenase inhibitors | HSD3B1, HSD3B2, HSD17B3 | NPC1 1239/4885RAB9A 3856/4885MEN1 2978/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.