Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | GABRA2 | P47869 | 5/20 | 0.44 |
| ▸ | GABRB2 | P47870 | 5/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11314005 | 0.85 | GAA (0.50) | GAACYP1A2KDM4EALDH1A1POLB | |
| SCHEMBL11328461 | 0.84 | MAPT (0.39) | GAACYP1A2KDM4EALDH1A1HPGD | |
| SCHEMBL11330451 | 0.83 | GAA (0.48) | GAACYP1A2KDM4EALDH1A1POLB | |
| SCHEMBL11330713 | 0.81 | GAA (0.46) | GAACYP1A2KDM4EALDH1A1POLB | |
| SCHEMBL17863723 | 0.79 | RAB9A (0.36) | CYP1A2KDM4ENPC1RAB9AMAPT | |
| SCHEMBL11317904 | 0.79 | GAA (0.47) | GAACYP1A2KDM4EALDH1A1POLB | |
| SCHEMBL2922603 | 0.76 | GAA (0.53) | GAACYP1A2KDM4EALDH1A1POLB | |
| SCHEMBL20518797 | 0.76 | MAPT (0.47) | GAACYP1A2KDM4EALDH1A1POLB | |
| SCHEMBL2930501 | 0.76 | GAA (0.56) | GAACYP1A2KDM4EALDH1A1POLB | |
| SCHEMBL2928930 | 0.75 | KDM4E (0.50) | GAACYP1A2KDM4EALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4267339-A | ANTIDIABETIC AGENTS | PLANTEX LTD. (IL) | 1981-05-12 | — | — | US | claimed |
| US-4137320-A | Pharmaceutical compositions containing imidazo(2,1-b)thiazoles and process for reducing blood sugar levels therewith | PLANTEX, LTD. (IL) | 1979-01-30 | — | — | US | claimed |
| US-4267339-A | ANTIDIABETIC AGENTS | PLANTEX LTD. (IL) | 1981-05-12 | — | — | US | disclosed |
| US-4137320-A | Pharmaceutical compositions containing imidazo(2,1-b)thiazoles and process for reducing blood sugar levels therewith | PLANTEX, LTD. (IL) | 1979-01-30 | — | — | US | disclosed |