Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.64 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.59 |
| ▸ | RAB9A | P51151 | 4/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | POLB | P06746 | 4/20 | 0.56 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.56 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.56 |
| ▸ | PKM | P14618 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.49 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18161206 | 0.88 | LMNA (0.78) | LMNACYP1A2CYP2C19MAPK1SMN1; SMN2 | |
| SCHEMBL4055792 | 0.83 | LMNA (0.71) | LMNACYP1A2CYP2C19MAPK1SMN1; SMN2 | |
| SCHEMBL11653005 | 0.83 | LMNA (0.71) | LMNACYP1A2CYP2C19SMN1; SMN2RAB9A | |
| SCHEMBL6174608 | 0.82 | LMNA (0.70) | LMNACYP1A2CYP2C19SMN1; SMN2CYP3A4 | |
| SCHEMBL11331468 | 0.82 | LMNA (0.69) | LMNACYP1A2CYP2C19MAPK1SMN1; SMN2 | |
| SCHEMBL224624 | 0.82 | CYP1A2 (0.72) | LMNACYP1A2CYP2C19MAPK1SMN1; SMN2 | |
| SCHEMBL8864119 | 0.82 | CYP1A2 (0.72) | LMNACYP1A2CYP2C19MAPK1SMN1; SMN2 | |
| SCHEMBL14554235 | 0.81 | LMNA (0.69) | LMNASMN1; SMN2RAB9AALDH1A1MEN1 | |
| SCHEMBL14353755 | 0.81 | LMNA (0.68) | LMNACYP1A2CYP2C19MAPK1SMN1; SMN2 | |
| SCHEMBL14353361 | 0.81 | LMNA (0.68) | LMNACYP1A2CYP2C19MAPK1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10272074-B2 | Inhibitors of glucocorticoid receptor translocation | Sanford Burnham Prebys Medical Discovery Institute (US) | 2019-04-30 | — | — | US | disclosed |
| US-20180207140-A1 | Pyrazolopyrimidines as Inhibitors of Glucocorticoid Receptor Translocation | Sanford Burnham Prebys Medical Discovery Institute | 2018-07-26 | — | — | US | disclosed |
| US-20180207140-A1 | Pyrazolopyrimidines as Inhibitors of Glucocorticoid Receptor Translocation | Sanford Burnham Prebys Medical Discovery Institute | 2018-07-26 | — | — | US | disclosed |
| WO-2016123392-A2 | PYRAZOLOPYRIMIDINES AS INHIBITORS OF GLUCOCORTICOID RECEPTOR TRANSLOCATION | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE (US) | 2016-08-04 | — | — | WO | disclosed |
| US-20130023534-A1 | PYRAZOLYL-PYRIMIDINES AS KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2013-01-24 | — | — | US | disclosed |
| US-20130023534-A1 | PYRAZOLYL-PYRIMIDINES AS KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2013-01-24 | — | — | US | disclosed |
| WO-2013004617-A1 | PYRAZOLOPYRIDINES USEFUL IN THE TREATMENT OF DISORDERS OF THE CENTRAL NERVOUS SYSTEM | H. LUNDBECK A/S (DK) | 2013-01-10 | — | — | WO | disclosed |
| WO-2013004617-A1 | PYRAZOLOPYRIDINES USEFUL IN THE TREATMENT OF DISORDERS OF THE CENTRAL NERVOUS SYSTEM | H. LUNDBECK A/S (DK) | 2013-01-10 | — | — | WO | disclosed |
| US-20130005743-A1 | New positive allosteric modulators of nicotinic acetylcholine receptor | H. LUNDBECK A/S (DK) | 2013-01-03 | — | — | US | disclosed |
| US-20130005743-A1 | New positive allosteric modulators of nicotinic acetylcholine receptor | H. LUNDBECK A/S (DK) | 2013-01-03 | — | — | US | disclosed |
| WO-2011120026-A1 | PYRAZOLYL-PYRIMIDINES AS KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2011-09-29 | — | — | WO | disclosed |
| US-4243584-A | Monoazo dyestuffs containing diazo component substituted by disulfimide and trifluoromethyl groups | BAYER AKTIENGESELLSCHAFT (DE) | 1981-01-06 | — | — | US | disclosed |
| US-4234594-A | Pyrazolyl amino imidazolines as antihypertensive agents | ABBOTT LABORATORIES (US) | 1980-11-18 | — | — | US | disclosed |
| US-4226773-A | Pyrazolyl amino imidazolines as diuretic agents | ABBOTT LABORATORIES (US) | 1980-10-07 | — | — | US | disclosed |
| US-4159265-A | Phenylazopyrazolo dyestuffs including disulfimide substituent | BAYER AKTIENGESELLSCHAFT (DE) | 1979-06-26 | — | — | US | disclosed |
| US-4134887-A | FIBER-REACTIVE | HOECHST AKTIENGESELLSCHAFT (DE) | 1979-01-16 | — | — | US | disclosed |
| US-4055557-A | MONOAZO DYES | BAYER AKTIENGESELLSCHAFT (DT) | 1977-10-25 | — | — | US | disclosed |
| US-4036825-A | DYES FOR CELLULOSE OR NITROGEN-CONTAINING FIBERS | HOECHST AKTIENGESELLSCHAFT (DT) | 1977-07-19 | — | — | US | disclosed |
| US-4017479-A | Cationic indazole-azo-5-amino pyrazole dyestuffs | CIBA-GEIGY AG (CH) | 1977-04-12 | — | — | US | disclosed |
| US-4006127-A | Cationic diazacyanine dyestuffs | BAYER AKTIENGESELLSCHAFT (DT) | 1977-02-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180207140-A1 | Pyrazolopyrimidines as Inhibitors of Glucocorticoid Receptor Translocation | NR3C1, NR3C2, GRK3 | LMNA 3725/4885CYP1A2 2328/4885CYP2C19 3447/4885 |
| US-20130005743-A1 | New positive allosteric modulators of nicotinic acetylcholine receptor | CHRNG, CHRNA7, CHRNA1 | LMNA 3278/4885CYP1A2 4134/4885CYP2C19 4372/4885 |
| US-10272074-B2 | Inhibitors of glucocorticoid receptor translocation | NR3C1, NR3C2, GRK3 | LMNA 3067/4885CYP1A2 3730/4885CYP2C19 4622/4885 |
| US-20130023534-A1 | PYRAZOLYL-PYRIMIDINES AS KINASE INHIBITORS | CDK2, MAP3K19, MAP3K1 | LMNA 2550/4885CYP1A2 2643/4885CYP2C19 1519/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.