Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 8/20 | 0.51 |
| ▸ | HTR2C | P28335 | 3/20 | 0.41 |
| ▸ | HTR2A | P28223 | 2/20 | 0.41 |
| ▸ | HTR2B | P41595 | 2/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.39 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.36 |
| ▸ | CD44 | P16070 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.34 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11338462 | 0.79 | PNMT (0.51) | PNMTHTR2CHTR2AHTR2BADRA2A | |
| SCHEMBL11340596 | 0.79 | PNMT (0.70) | PNMTHTR2CHTR2AHTR2BADRA2A | |
| SCHEMBL11325747 | 0.79 | PNMT (0.70) | PNMTHTR2CHTR2AHTR2BADRA2A | |
| SCHEMBL11335549 | 0.79 | PNMT (0.51) | PNMTHTR2CHTR2AHTR2BADRA2A | |
| SCHEMBL11339611 | 0.79 | PNMT (0.51) | PNMTADRA2AADRA2BADRA2CCD44 | |
| SCHEMBL11344665 | 0.78 | PNMT (0.46) | PNMTHTR2CHTR2AHTR2BADRA2A | |
| SCHEMBL11324903 | 0.78 | PNMT (0.51) | PNMTADRA2AADRA2BADRA2C | |
| SCHEMBL29573959 | 0.77 | NOS3 (0.39) | HTR2CHTR2AHTR2B | |
| SCHEMBL20634317 | 0.77 | NOS3 (0.39) | HTR2CHTR2AHTR2B | |
| Hydrochloric Acid SCHEMBL30150929 | 0.76 | NOS3 (0.38) | HTR2CHTR2AHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0002624-B1 | 2-BENZAZEPINE COMPOUNDS, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SMITHKLINE BECKMAN CORPORATION (US) | 1981-10-14 | — | — | EP | disclosed |
| EP-0002624-A1 | 2-Benzazepine compounds, processes for their preparation and pharmaceutical compositions containing them | SMITHKLINE BECKMAN CORPORATION (US) | 1979-06-27 | — | — | EP | disclosed |