Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.50 |
| ▸ | PNMT | P11086 | 7/20 | 0.47 |
| ▸ | HTR2A | P28223 | 3/20 | 0.45 |
| ▸ | HTR2C | P28335 | 3/20 | 0.45 |
| ▸ | HTR2B | P41595 | 3/20 | 0.45 |
| ▸ | PARP1 | P09874 | 1/20 | 0.44 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL183621 | 0.89 | ASIC3 (0.60) | ASIC3PNMTHTR2AHTR2CHTR2B | |
| SCHEMBL29808272 | 0.89 | ASIC3 (0.60) | ASIC3PNMTHTR2AHTR2CHTR2B | |
| Hydrochloric Acid SCHEMBL1000239 | 0.88 | ASIC3 (0.59) | ASIC3PNMTHTR2AHTR2CHTR2B | |
| SCHEMBL329770 | 0.82 | ASIC3 (0.69) | ASIC3PNMTHTR2AHTR2CHTR2B | |
| SCHEMBL2310562 | 0.81 | PNMT (0.56) | ASIC3PNMTHTR2AHTR2CHTR2B | |
| SCHEMBL29835145 | 0.81 | PNMT (0.56) | ASIC3PNMTHTR2AHTR2CHTR2B | |
| Hydrochloric Acid SCHEMBL1000104 | 0.81 | ASIC3 (0.68) | ASIC3PNMTHTR2AHTR2CHTR2B | |
| Hydrochloric Acid SCHEMBL1647036 | 0.80 | PNMT (0.54) | ASIC3PNMTHTR2AHTR2CHTR2B | |
| Hydrochloric Acid SCHEMBL29627981 | 0.80 | PNMT (0.54) | ASIC3PNMTHTR2AHTR2CHTR2B | |
| Bromide SCHEMBL2310632 | 0.80 | PNMT (0.54) | ASIC3PNMTHTR2AHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0002624-B1 | 2-BENZAZEPINE COMPOUNDS, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SMITHKLINE BECKMAN CORPORATION (US) | 1981-10-14 | — | — | EP | disclosed |
| EP-0002624-A1 | 2-Benzazepine compounds, processes for their preparation and pharmaceutical compositions containing them | SMITHKLINE BECKMAN CORPORATION (US) | 1979-06-27 | — | — | EP | disclosed |