Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 2/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.38 |
| ▸ | PRCP | P42785 | 6/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11331893 | 0.83 | OPRD1 (0.44) | OPRD1KCNH2SIGMAR1PRCPADRA2A | |
| Hydrochloric Acid SCHEMBL11326680 | 0.82 | OPRD1 (0.43) | OPRD1KCNH2SIGMAR1PRCPADRA2A | |
| SCHEMBL11334162 | 0.81 | OPRD1 (0.49) | OPRD1KCNH2SIGMAR1PRCPOPRM1 | |
| SCHEMBL11334163 | 0.81 | OPRD1 (0.49) | OPRD1KCNH2SIGMAR1PRCPOPRM1 | |
| SCHEMBL11840739 | 0.78 | OPRD1 (0.51) | OPRD1KCNH2SIGMAR1PRCPOPRM1 | |
| SCHEMBL11684960 | 0.77 | OPRD1 (0.57) | OPRD1KCNH2SIGMAR1PRCPOPRM1 | |
| SCHEMBL11845021 | 0.77 | OPRD1 (0.50) | OPRD1KCNH2SIGMAR1PRCPOPRM1 | |
| SCHEMBL4363631 | 0.77 | OPRD1 (0.50) | OPRD1KCNH2SIGMAR1PRCPOPRM1 | |
| SCHEMBL29705809 | 0.77 | OPRD1 (0.50) | OPRD1KCNH2SIGMAR1PRCPOPRM1 | |
| SCHEMBL11368769 | 0.75 | OPRD1 (0.52) | OPRD1KCNH2SIGMAR1PRCPOPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4290958-A | Spiro[cyclohexane-1,1'(3'H)-isobenzofuran]s | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1981-09-22 | — | — | US | claimed |
| US-4301292-A | 1-[2-(4,5-Dihydro-4,4-dialkyl-2-oxazolyl)phenyl]-4-(dialkylamino)cyclohexanol | HOECHST-ROUSSEL PHARMACEUTICALS, INCORPORATED (US) | 1981-11-17 | — | — | US | disclosed |
| US-4292245-A | 3'-Phenylspiro[cyclohexane-1,1'(3'H)-isobenzofuran]-4-one | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1981-09-29 | — | — | US | disclosed |
| US-4292243-A | 3\"-Phenyldispiro[1,3-dioxolane-2,4'-cyclohexane-1',1\"-(3\"H)-isobenzofuran] | HOECHST ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1981-09-29 | — | — | US | disclosed |
| US-4290958-A | Spiro[cyclohexane-1,1'(3'H)-isobenzofuran]s | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1981-09-22 | — | — | US | disclosed |
| US-4288623-A | 1-Aryl-4-amino-cyclohexan-1-ols | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1981-09-08 | — | — | US | disclosed |
| EP-0027522-A1 | Spiro(cyclohexane-1,1'(3'H)-isobenzofuran)s, processes and intermediates for their preparation and pharmaceutical compositions containing them | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1981-04-29 | — | — | EP | disclosed |
| US-4263317-A | Spiro[cyclohexane-1,1'(3'H)-isobenzofuran]s | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1981-04-21 | — | — | US | disclosed |