Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 2/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.52 |
| ▸ | PRCP | P42785 | 6/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.38 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11334157 | 0.98 | OPRD1 (0.51) | OPRD1KCNH2PRCPSIGMAR1OPRL1 | |
| SCHEMBL11840739 | 0.81 | OPRD1 (0.51) | OPRD1KCNH2PRCPSIGMAR1OPRM1 | |
| SCHEMBL11323825 | 0.81 | OPRD1 (0.46) | OPRD1KCNH2PRCPSIGMAR1OPRM1 | |
| SCHEMBL11326247 | 0.81 | OPRD1 (0.46) | OPRD1KCNH2PRCPSIGMAR1KDM1A | |
| SCHEMBL11323828 | 0.81 | OPRD1 (0.46) | OPRD1KCNH2PRCPSIGMAR1OPRM1 | |
| SCHEMBL11326244 | 0.81 | OPRD1 (0.46) | OPRD1KCNH2PRCPSIGMAR1KDM1A | |
| SCHEMBL11681373 | 0.81 | OPRD1 (0.60) | OPRD1KCNH2PRCPSIGMAR1OPRM1 | |
| Hydrochloric Acid SCHEMBL11331866 | 0.80 | OPRD1 (0.46) | OPRD1KCNH2PRCPSIGMAR1KDM1A | |
| Hydrochloric Acid SCHEMBL11330675 | 0.80 | OPRD1 (0.46) | OPRD1KCNH2PRCPSIGMAR1KDM1A | |
| SCHEMBL11845021 | 0.80 | OPRD1 (0.50) | OPRD1KCNH2PRCPSIGMAR1OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0027522-A1 | Spiro(cyclohexane-1,1'(3'H)-isobenzofuran)s, processes and intermediates for their preparation and pharmaceutical compositions containing them | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1981-04-29 | — | — | EP | claimed |
| US-4263317-A | Spiro[cyclohexane-1,1'(3'H)-isobenzofuran]s | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1981-04-21 | — | — | US | claimed |