Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | PNMT | P11086 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.43 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.42 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | MITF | O75030 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11478363 | 0.92 | NOTUM (0.58) | NOTUMHRH3SMN1; SMN2PNMTLMNA | |
| SCHEMBL11322167 | 0.88 | NOTUM (0.47) | NOTUMHRH3ALDH1A1SMN1; SMN2TP53 | |
| SCHEMBL11336330 | 0.88 | CA1 (0.56) | NOTUMHRH3ALDH1A1SMN1; SMN2PNMT | |
| SCHEMBL21729633 | 0.85 | NOTUM (0.55) | NOTUMPNMTUSP30 | |
| SCHEMBL11324820 | 0.84 | PNMT (0.47) | NOTUMHRH3ALDH1A1SMN1; SMN2PNMT | |
| SCHEMBL11550415 | 0.84 | NOTUM (0.43) | NOTUMHRH3ALDH1A1SMN1; SMN2TP53 | |
| SCHEMBL4035842 | 0.82 | PNMT (0.49) | NOTUMHRH3ALDH1A1SMN1; SMN2PNMT | |
| SCHEMBL12013933 | 0.80 | NOTUM (0.53) | NOTUMHRH3ALDH1A1RIPK1MCHR1 | |
| SCHEMBL1074701 | 0.79 | NOTUM (0.56) | NOTUMHRH3ALDH1A1SMN1; SMN2MCHR1 | |
| SCHEMBL11327160 | 0.78 | NR1H2 (0.56) | NOTUMHRH3RIPK1MCHR1BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0002624-B1 | 2-BENZAZEPINE COMPOUNDS, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SMITHKLINE BECKMAN CORPORATION (US) | 1981-10-14 | — | — | EP | disclosed |
| EP-0002624-A1 | 2-Benzazepine compounds, processes for their preparation and pharmaceutical compositions containing them | SMITHKLINE BECKMAN CORPORATION (US) | 1979-06-27 | — | — | EP | disclosed |