Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.55 |
| ▸ | SLC6A9 | P48067 | 8/20 | 0.44 |
| ▸ | SLC6A5 | Q9Y345 | 3/20 | 0.44 |
| ▸ | PNMT | P11086 | 3/20 | 0.44 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.44 |
| ▸ | TMEM97 | Q5BJF2 | 4/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11478363 | 0.88 | NOTUM (0.58) | NOTUMPNMT | |
| SCHEMBL6923184 | 0.85 | NOTUM (0.53) | NOTUM | |
| SCHEMBL11325713 | 0.85 | NOTUM (0.48) | NOTUMPNMTUSP30 | |
| SCHEMBL4035842 | 0.81 | PNMT (0.49) | NOTUMPNMT | |
| SCHEMBL18971976 | 0.80 | NAMPT (0.54) | SLC6A9SLC6A5PNMTUSP30TMEM97 | |
| SCHEMBL18022672 | 0.79 | ESR2 (0.53) | TMEM97KCNH2SIGMAR1 | |
| SCHEMBL18971905 | 0.78 | DPP7 (0.45) | SLC6A9SLC6A5TMEM97KCNH2SIGMAR1 | |
| SCHEMBL14067246 | 0.78 | NAMPT (0.55) | NOTUM | |
| SCHEMBL10150901 | 0.75 | NOTUM (0.62) | NOTUM | |
| SCHEMBL14067114 | 0.75 | NOTUM (0.62) | NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020035556-A1 | NOVEL HETEROAROMATIC MODULATORS OF THE RETINOID-RELATED ORPHAN RECEPTOR GAMMA | LEO PHARMA A/S (DK) | 2020-02-20 | — | — | WO | disclosed |