Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 8/20 | 0.34 |
| ▸ | RAB9A | P51151 | 8/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.33 |
| ▸ | MGLL | Q99685 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | MITF | O75030 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | FAAH | O00519 | 1/20 | 0.33 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.32 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.32 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 5/20 | 0.31 |
| ▸ | LMNA | P02545 | 3/20 | 0.31 |
| ▸ | APOBEC3A | P31941 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10379020 | 0.98 | PTGS1 (0.36) | NPC1RAB9AALDH1A1MEN1KMT2A | |
| SCHEMBL7204901 | 0.88 | NPC1 (0.41) | NPC1RAB9AALDH1A1MEN1KMT2A | |
| SCHEMBL28203676 | 0.86 | NPC1 (0.42) | NPC1RAB9AALDH1A1MEN1KMT2A | |
| SCHEMBL27263110 | 0.86 | NPC1 (0.42) | NPC1RAB9AALDH1A1MEN1KMT2A | |
| SCHEMBL74210 | 0.83 | — | — | |
| SCHEMBL12613800 | 0.80 | ALDH1A1 (0.39) | NPC1RAB9AALDH1A1MEN1KMT2A | |
| Hno SCHEMBL28259195 | 0.78 | NPC1 (0.41) | NPC1RAB9AALDH1A1MEN1KMT2A | |
| SCHEMBL18838747 | 0.75 | NPC1 (0.44) | NPC1RAB9AALDH1A1MEN1KMT2A | |
| SCHEMBL4270831 | 0.72 | TSHR (0.47) | NPC1RAB9AALDH1A1MEN1KMT2A | |
| SCHEMBL546776 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2286804-A1 | A method of treating degenerative disc disease | DePuy Spine, Inc. (US) | 2011-02-23 | — | — | EP | claimed |
| US-20050025765-A1 | Trans-capsular administration of high specificity cytokine inhibitors into orthopedic joints | DEPUY SPINE, INC. (US) | 2005-02-03 | — | — | US | claimed |
| US-20040229878-A1 | Transdiscal administration of specific inhibitors of P38 kinase | DEPUY SPINE, INC. (US) | 2004-11-18 | — | — | US | claimed |
| US-RE49219-E1 | Local intraosseous administration of bone forming agents and anti-resorptive agents, and devices therefor | DePuy Synthes Products, Inc. (US) | 2022-09-27 | — | — | US | disclosed |
| US-8986696-B2 | Trans-capsular administration of p38 map kinase inhibitors into orthopedic joints | DEPUY MITEK, INC. (US) | 2015-03-24 | — | — | US | disclosed |
| US-8895540-B2 | Local intraosseous administration of bone forming agents and anti-resorptive agents, and devices therefor | DePuy Synthes Products, LLC (US) | 2014-11-25 | — | — | US | disclosed |
| US-8361467-B2 | Antagonist is selected from an antioxidant or an inhibitor of a pro-inflammatory interleukin, TNF- alpha synthesis, membrane-bound TNF- alpha, a natural receptor of TNF- alpha, nitric oxide synthase, phospholipase A2, apoptosis, matrix metalloproteases, or p38 kinase | DEPUY SPINE, INC. (US) | 2013-01-29 | — | — | US | disclosed |
| US-8067397-B2 | Transdiscal administration of cycline compounds | DEPUY SPINE, INC. (US) | 2011-11-29 | — | — | US | disclosed |
| EP-2286804-A1 | A method of treating degenerative disc disease | DePuy Spine, Inc. (US) | 2011-02-23 | — | — | EP | disclosed |
| US-20090324558-A1 | Transdiscal administration of cycline compounds | DEPUY SPINE, INC. (US) | 2009-12-31 | — | — | US | disclosed |
| US-7553827-B2 | Transdiscal administration of cycline compounds | DEPUY SPINE, INC. (US) | 2009-06-30 | — | — | US | disclosed |
| US-20090162376-A1 | Trans-capsular administration of p38 map kinase inhibitors into orthopedic joints | DEPUY MITEK, LLC | 2009-06-25 | — | — | US | disclosed |
| EP-1675589-A2 | TREATMENT OF INFLAMED JOINTS | DePuy Spine, Inc. (US) | 2006-07-05 | — | — | EP | disclosed |
| EP-1631266-A2 | A METHOD OF TREATING DEGENERATIVE DISC DISEASE | DePuy Spine, Inc. (US) | 2006-03-08 | — | — | EP | disclosed |
| US-20050112091-A1 | Osteoporosis mixture of bone forming agents and nonabsorbent | DEPUY SPINE, INC. (US) | 2005-05-26 | — | — | US | disclosed |
| US-20050038001-A1 | Transdiscal administration of cycline compounds | DEPUY SPINE, INC. (US) | 2005-02-17 | — | — | US | disclosed |
| WO-2005011689-A2 | TREATMENT OF INFLAMED JOINTS | DEPUY SPINE, INC. (US) | 2005-02-10 | — | — | WO | disclosed |
| US-20050025765-A1 | Trans-capsular administration of high specificity cytokine inhibitors into orthopedic joints | DEPUY SPINE, INC. (US) | 2005-02-03 | — | — | US | disclosed |
| WO-2005000283-A2 | A METHOD OF TREATING DEGENERATIVE DISC DISEASE | DEPUY SPINE, INC. (US) | 2005-01-06 | — | — | WO | disclosed |
| US-20040229878-A1 | Transdiscal administration of specific inhibitors of P38 kinase | DEPUY SPINE, INC. (US) | 2004-11-18 | — | — | US | disclosed |