Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 9/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.41 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.41 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11478357 | 0.89 | PNMT (0.51) | PNMTADRA2AADRA2BADRA2CDRD2 | |
| SCHEMBL11339773 | 0.81 | PNMT (0.44) | PNMTADRA2AADRA2BADRA2CDRD2 | |
| SCHEMBL11331794 | 0.80 | PNMT (0.38) | PNMTADRA2AADRA2BADRA2CDRD2 | |
| SCHEMBL10564473 | 0.80 | HTR2C (0.48) | PNMTADRA2AADRA2BADRA2CDRD2 | |
| Hydrochloric Acid SCHEMBL10351372 | 0.78 | HTR2C (0.47) | PNMTADRA2AADRA2BADRA2CDRD2 | |
| SCHEMBL21254761 | 0.75 | CA12 (0.40) | — | |
| SCHEMBL17813307 | 0.74 | PNMT (0.47) | PNMTADRA2AADRA2BADRA2CDRD2 | |
| SCHEMBL11340594 | 0.71 | PNMT (0.82) | PNMTADRA2AADRA2BADRA2C | |
| SCHEMBL25207974 | 0.70 | PNMT (0.79) | PNMTADRA2AADRA2BADRA2CDRD2 | |
| SCHEMBL1849383 | 0.70 | PNMT (0.79) | PNMTADRA2AADRA2BADRA2CDRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0002624-B1 | 2-BENZAZEPINE COMPOUNDS, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SMITHKLINE BECKMAN CORPORATION (US) | 1981-10-14 | — | — | EP | disclosed |
| EP-0002624-A1 | 2-Benzazepine compounds, processes for their preparation and pharmaceutical compositions containing them | SMITHKLINE BECKMAN CORPORATION (US) | 1979-06-27 | — | — | EP | disclosed |