Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 12/20 | 0.48 |
| ▸ | HTR2B | P41595 | 11/20 | 0.48 |
| ▸ | HTR2A | P28223 | 1/20 | 0.48 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | DRD1 | P21728 | 1/20 | 0.41 |
| ▸ | ADCY6 | O43306 | 1/20 | 0.41 |
| ▸ | ADCY3 | O60266 | 1/20 | 0.41 |
| ▸ | ADCY9 | O60503 | 1/20 | 0.41 |
| ▸ | ADCY5 | O95622 | 1/20 | 0.41 |
| ▸ | ADCY8 | P40145 | 1/20 | 0.41 |
| ▸ | ADCY7 | P51828 | 1/20 | 0.41 |
| ▸ | ADCY2 | Q08462 | 1/20 | 0.41 |
| ▸ | ADCY1 | Q08828 | 1/20 | 0.41 |
| ▸ | ADCY4 | Q8NFM4 | 1/20 | 0.41 |
| ▸ | PNMT | P11086 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL10351372 | 0.98 | HTR2C (0.47) | HTR2CHTR2BHTR2ADRD2DRD1 | |
| Hydrochloric Acid SCHEMBL11478357 | 0.88 | PNMT (0.51) | DRD2PNMTADRA2AADRA2BADRA2C | |
| SCHEMBL11328613 | 0.80 | PNMT (0.43) | DRD2PNMTADRA2AADRA2BADRA2C | |
| SCHEMBL3238935 | 0.76 | DRD2 (0.50) | DRD2HRH3 | |
| SCHEMBL10567329 | 0.70 | ADCY6 (0.41) | HTR2CHTR2BHTR2ADRD2DRD1 | |
| SCHEMBL10350533 | 0.70 | NOTUM (0.47) | HRH3 | |
| SCHEMBL21254761 | 0.70 | CA12 (0.40) | HRH3 | |
| SCHEMBL10232037 | 0.70 | HTR2C (0.57) | HTR2CHTR2BHTR2ADRD2DRD1 | |
| Hydrochloric Acid SCHEMBL10350476 | 0.69 | ADCY6 (0.39) | HTR2CHTR2BHTR2ADRD2DRD1 | |
| SCHEMBL10564212 | 0.69 | HTR2C (0.43) | HTR2CHTR2BHTR2ADRD2DRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4824839-A | Sulfinyl and sulfonyl substituted 2,3,4,5 tetrahydro-1H-3-benzazepines and their use in treating gastrointestinal motility disorders | SMITHKLINE BECKMAN CORPORATION (US) | 1989-04-25 | — | — | US | disclosed |