SCHEMBL1132899

SCHEMBL1132899

CO[Si](CCCN(CCNC(C)=O)C(C)=O)(OC)OC

nearest known ligand 0.39

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
MTNR1A P48039 16/20 0.39
MTNR1B P49286 16/20 0.39
KDM4E B2RXH2 1/20 0.38
MAPK1 P28482 1/20 0.38
HIF1A Q16665 1/20 0.38
CYP1A2 P05177 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19775776 0.88 LMNA (0.32)
SCHEMBL18310182 0.82 KDM4E (0.50) MTNR1AMTNR1BKDM4EMAPK1HIF1A
SCHEMBL19970469 0.81 CA12 (0.41) KDM4EMAPK1CYP1A2
SCHEMBL22477356 0.81 LMNA (0.36) MAPK1CYP1A2
SCHEMBL13824881 0.81 KDM4E (0.54) MTNR1AMTNR1BKDM4EMAPK1HIF1A
SCHEMBL8428056 0.80 KDM4E (0.50) MTNR1AMTNR1BKDM4EMAPK1HIF1A
SCHEMBL960689 0.79 KDM4E (0.56) MTNR1AMTNR1BKDM4EMAPK1HIF1A
SCHEMBL10724003 0.78 KDM4E (0.48) MTNR1AMTNR1BKDM4EMAPK1HIF1A
SCHEMBL19821143 0.77 LMNA (0.30)
SCHEMBL20467882 0.77

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2287261-B1 Method of Preparing an Aqueous Oligomeric or Polymeric Compound SIGMA COATINGS BV (NL) 2020-09-02 EP disclosed
US-20130289190-A1 Binder Composition PPG B.V. (NL) 2013-10-31 US disclosed
US-20130267643-A1 Binder Composition PPG B.V. (NL) 2013-10-10 US disclosed
EP-1853675-B1 A BINDER COMPOSITION SIGMA COATINGS BV (NL) 2011-07-27 EP disclosed
US-20110098397-A1 Binder Composition PPG B.V. (NL) 2011-04-28 US disclosed
EP-2287261-A2 Method of Preparing an Aqueous Oligomeric or Polymeric Compound SIGMA COATINGS B.V. (NL) 2011-02-23 EP disclosed
EP-1853675-A2 A BINDER COMPOSITION SIGMA COATINGS B.V. (NL) 2007-11-14 EP disclosed
WO-2006079516-A2 A BINDER COMPOSITION SIGMA COATINGS B.V. (NL) 2006-08-03 WO disclosed