Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | DHFR | P00374 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | CACNA1D | Q01668 | 3/20 | 0.39 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.39 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.39 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11344156 | 0.89 | ADORA3 (0.48) | ADORA3KDM4EGAAALDH1A1DHFR | |
| SCHEMBL11322719 | 0.88 | ABCC1 (0.53) | KDM4EGAAALDH1A1SMN1; SMN2CACNA1D | |
| SCHEMBL11337673 | 0.86 | CACNA1F (0.44) | ADORA3CACNA1DCACNA1FCACNA1SCACNA1C | |
| SCHEMBL11335061 | 0.85 | ADORA3 (0.45) | ADORA3KDM4EGAAALDH1A1DHFR | |
| SCHEMBL11331965 | 0.84 | CACNA1F (0.47) | ADORA3ALDH1A1CACNA1DCACNA1FCACNA1S | |
| SCHEMBL11350210 | 0.84 | CACNA1C (0.61) | ADORA3CACNA1DCACNA1FCACNA1SCACNA1C | |
| SCHEMBL11338038 | 0.83 | TSHR (0.45) | ADORA3KDM4EGAAALDH1A1CACNA1D | |
| SCHEMBL7322941 | 0.83 | ADORA3 (0.58) | ADORA3KDM4EGAAALDH1A1DHFR | |
| SCHEMBL11260609 | 0.82 | ADORA3 (0.59) | ADORA3KDM4EGAAALDH1A1DHFR | |
| SCHEMBL11335560 | 0.82 | MAPT (0.47) | KDM4EALDH1A1CACNA1CMAPTCASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0001108-B1 | 1,4-DIHYDROPYRIDAZINES, PROCESS FOR THEIR PREPARATION AND THEIR USE IN PHARMACEUTICALS | BAYER AG (DE) | 1981-04-29 | — | — | EP | disclosed |