Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | CACNA1D | Q01668 | 2/20 | 0.47 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.47 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.47 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.47 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.47 |
| ▸ | DHFR | P00374 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10530880 | 0.92 | ADORA3 (0.50) | ADORA3KDM4EALDH1A1GAATSHR | |
| SCHEMBL10786897 | 0.86 | ADORA3 (0.52) | ADORA3KDM4EALDH1A1GAATSHR | |
| SCHEMBL11350249 | 0.86 | ADORA3 (0.47) | ADORA3KDM4EALDH1A1GAATSHR | |
| SCHEMBL9369030 | 0.85 | CACNA1F (0.49) | ADORA3KDM4EALDH1A1GAATSHR | |
| SCHEMBL11344156 | 0.84 | ADORA3 (0.48) | ADORA3KDM4EALDH1A1GAATSHR | |
| SCHEMBL11005887 | 0.84 | CACNA1B (0.49) | ADORA3CACNA1DCACNA1FCACNA1SCACNA1C | |
| SCHEMBL7298685 | 0.83 | ADORA3 (0.45) | ADORA3KDM4EALDH1A1GAATSHR | |
| SCHEMBL9359378 | 0.83 | ADORA3 (0.47) | ADORA3KDM4EALDH1A1GAATSHR | |
| SCHEMBL11329664 | 0.83 | ADORA3 (0.47) | ADORA3KDM4EALDH1A1GAATSHR | |
| SCHEMBL9691613 | 0.82 | ADORA3 (0.49) | ADORA3KDM4EALDH1A1GAATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0288758-B1 | DIHYDROPYRIDINAMIDES, PROCESS FOR THEIR PREPARATION AND THEIR USE IN MEDICINES | BAYER AG (DE) | 1991-08-14 | — | — | EP | disclosed |
| EP-0229381-B1 | METHIONINE-SUBSTITUTED 1,4-DIHYDROPYRIDINES, PROCESS FOR THE PREPARATION AND THEIR USE | BAYER AG (DE) | 1990-05-30 | — | — | EP | disclosed |
| EP-0362632-A2 | Basic 4-aryl-DHP amides, process for their preparation and their pharmaceutical use | BAYER AG (DE) | 1990-04-11 | — | — | EP | disclosed |
| EP-0288758-A2 | Dihydropyridinamides, process for their preparation and their use in medicines | BAYER AG (DE) | 1988-11-02 | — | — | EP | disclosed |
| EP-0236838-A2 | Aminoester-dihydropyridines, process for their preparation and their use | BAYER AG (DE) | 1987-09-16 | — | — | EP | disclosed |
| EP-0229381-A1 | Methionine-substituted 1,4-dihydropyridines, process for the preparation and their use | BAYER AG (DE) | 1987-07-22 | — | — | EP | disclosed |
| EP-0218068-A1 | Dihydropyridine-2-hydroxyamines, process for their preparation and their use in medicaments | BAYER AG (DE) | 1987-04-15 | — | — | EP | disclosed |
| EP-0110259-B1 | 1,4-DIHYDROPYRIDINES, PROCESSES FOR THEIR PREPARATION AND THEIR USE IN MEDICINES | BAYER AG (DE) | 1986-12-17 | — | — | EP | disclosed |
| EP-0199238-A1 | 1,4-Dihydropyridine derivatives, process for their preparation and their use in medicaments | BAYER AG (DE) | 1986-10-29 | — | — | EP | disclosed |
| EP-0088274-B1 | 1,4-DIHYDROPYRIDINES, PROCESS FOR THEIR PREPARATION AND THEIR APPLICATION AS PHARMACEUTICAL PREPARATIONS | BAYER AG (DE) | 1986-09-03 | — | — | EP | disclosed |
| EP-0179386-A2 | 1,4-Dihydropyridine hydroxyamines, process for their preparation and their use as pharmaceutical agents | BAYER AG (DE) | 1986-04-30 | — | — | EP | disclosed |
| EP-0088276-B1 | COMPOUNDS, PROCESS FOR THEIR PREPARATION AND THEIR USE AS PHARMACEUTICAL PREPARATIONS | BAYER AG (DE) | 1986-04-30 | — | — | EP | disclosed |
| EP-0110259-A1 | 1,4-Dihydropyridines, processes for their preparation and their use in medicines | BAYER AG (DE) | 1984-06-13 | — | — | EP | disclosed |
| EP-0104550-A2 | Condensed 1,4-dihydropyridines, process for their preparation and their application as pharmaceutical products | BAYER AG (DE) | 1984-04-04 | — | — | EP | disclosed |
| EP-0088276-A1 | Compounds, process for their preparation and their use as pharmaceutical preparations | BAYER AG (DE) | 1983-09-14 | — | — | EP | disclosed |
| EP-0088274-A1 | 1,4-Dihydropyridines, process for their preparation and their application as pharmaceutical preparations | BAYER AG (DE) | 1983-09-14 | — | — | EP | disclosed |
| EP-0039863-A1 | 1,4-Dihydropyridines with different substituents in positions 2 and 6, processes for their preparation and their use in medicines | BAYER AG (DE) | 1981-11-18 | — | — | EP | disclosed |