Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 11/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | THRB | P10828 | 2/20 | 0.43 |
| ▸ | RECQL | P46063 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | INSR | P06213 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL3288546 | 0.82 | MAPT (0.68) | MAPTKDM4ETHRBRECQLCYP2D6 | |
| Bromide SCHEMBL7762935 | 0.80 | CYP2D6 (0.60) | MAPTKDM4ETHRBRECQLCYP2D6 | |
| Bromide SCHEMBL3284767 | 0.79 | MAPT (0.53) | MAPTKDM4ETHRBRECQLCYP2D6 | |
| SCHEMBL13646785 | 0.78 | CYP2D6 (0.66) | MAPTKDM4ETHRBRECQLCYP2D6 | |
| SCHEMBL1048707 | 0.77 | MAPT (0.54) | MAPTKDM4ETHRBRECQLCYP2D6 | |
| Iodide SCHEMBL11883305 | 0.77 | CYP2D6 (0.60) | MAPTKDM4ETHRBRECQLCYP2D6 | |
| Iodide SCHEMBL4012476 | 0.76 | MAPT (0.57) | MAPTKDM4ETHRBRECQLCYP2D6 | |
| SCHEMBL12201210 | 0.75 | KDM4E (0.51) | MAPTKDM4ETHRBRECQLCYP2D6 | |
| SCHEMBL8517706 | 0.75 | MAPT (0.77) | MAPTKDM4ETHRBRECQLCYP2D6 | |
| SCHEMBL9226505 | 0.75 | MAPT (0.62) | MAPTKDM4ETHRBRECQLCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4279987-A | 2,5-DIHYDROXY-BIPHENYL COMPOUNDS ADDED AS DEVELOPMENT ACCELERATORS | KONISHIROKU PHOTO INDUSTRY CO., LTD. (JP) | 1981-07-21 | — | — | US | disclosed |
| US-4268621-A | Direct positive photographic material | KONISHIROKU PHOTO INDUSTRY CO., LTD. (JP) | 1981-05-19 | — | — | US | disclosed |
| US-4150993-A | AMINEBORANE COMPOUND | KONISHIROKU PHOTO INDUSTRY CO., LTD. (JP) | 1979-04-24 | — | — | US | disclosed |