Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 12/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 2/20 | 0.41 |
| ▸ | MPI | P34949 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1048707 | 0.98 | MAPT (0.54) | MAPTKDM4ELMNAPOLBHPGD | |
| Iodide SCHEMBL4012476 | 0.97 | MAPT (0.57) | MAPTKDM4ELMNAPOLBHPGD | |
| Bromide SCHEMBL3288546 | 0.84 | MAPT (0.68) | MAPTKDM4ELMNAPOLBHPGD | |
| SCHEMBL7030602 | 0.83 | MAPT (0.50) | MAPTKDM4ELMNAPOLBHPGD | |
| Bromide SCHEMBL11597613 | 0.81 | MAPT (0.42) | MAPTKDM4ELMNAPOLBHPGD | |
| SCHEMBL12364566 | 0.81 | MAPT (0.72) | MAPTKDM4ELMNAPOLBHPGD | |
| Bromide SCHEMBL3280970 | 0.80 | MAPT (0.53) | MAPTKDM4ELMNAPOLBHPGD | |
| Iodide SCHEMBL10890986 | 0.79 | MAPT (0.75) | MAPTKDM4ELMNAPOLBHPGD | |
| Bromide SCHEMBL11330583 | 0.79 | MAPT (0.47) | MAPTKDM4ELMNAPOLBHPGD | |
| Bromide SCHEMBL11136857 | 0.78 | MAPT (0.40) | MAPTKDM4ELMNAPOLBHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7709653-B2 | Asymmetric cyanine compounds, their preparation methods and their uses | SHENZHEN MINDRAY BIO-MEDICAL ELECTRONICS CO. LTD. (CN) | 2010-05-04 | — | — | US | disclosed |
| US-20090305285-A1 | ASYMMETRIC CYANINE COMPOUNDS, THEIR PREPARATION METHODS AND THEIR USES | SHENZHEN MINDRAY BIO-MEDICAL ELECTRONICS CO., LTD. (CN) | 2009-12-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090305285-A1 | ASYMMETRIC CYANINE COMPOUNDS, THEIR PREPARATION METHODS AND THEIR USES | IK, RCN1, RCC1 | MAPT 4522/4885KDM4E 2407/4885LMNA 117/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.