Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 5/20 | 0.79 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.49 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.49 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.49 |
| ▸ | PRCP | P42785 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.44 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | CD44 | P16070 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 2/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1852509 | 0.89 | PNMT (1.00) | PNMTADRA2AADRA2BADRA2CPRCP | |
| Ammonia Solution, Strong SCHEMBL20358513 | 0.87 | PNMT (0.96) | PNMTADRA2AADRA2BADRA2CPRCP | |
| Hydrochloric Acid SCHEMBL1124149 | 0.87 | PNMT (0.96) | PNMTADRA2AADRA2BADRA2CPRCP | |
| SCHEMBL11325485 | 0.85 | PNMT (0.62) | PNMTADRA2AADRA2BADRA2CCYP2D6 | |
| SCHEMBL3171440 | 0.78 | PNMT (0.68) | PNMTADRA2AADRA2BADRA2CCYP2D6 | |
| SCHEMBL31158975 | 0.78 | PNMT (0.68) | PNMTADRA2AADRA2BADRA2CCYP2D6 | |
| SCHEMBL14692360 | 0.78 | PNMT (0.50) | PNMTPRCPCD44HTR2CHTR2B | |
| SCHEMBL19684566 | 0.78 | PNMT (0.50) | PNMTPRCPCD44HTR2C | |
| SCHEMBL11327500 | 0.78 | PNMT (0.50) | PNMTPRCPCD44HTR2CHTR2B | |
| SCHEMBL476330 | 0.78 | PNMT (1.00) | PNMTADRA2AADRA2BADRA2CHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0002624-B1 | 2-BENZAZEPINE COMPOUNDS, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SMITHKLINE BECKMAN CORPORATION (US) | 1981-10-14 | — | — | EP | disclosed |
| EP-0002624-A1 | 2-Benzazepine compounds, processes for their preparation and pharmaceutical compositions containing them | SMITHKLINE BECKMAN CORPORATION (US) | 1979-06-27 | — | — | EP | disclosed |