Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | ITGA4 | P13612 | 2/20 | 0.39 |
| ▸ | ITGB7 | P26010 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | ABCC4 | O15439 | 2/20 | 0.39 |
| ▸ | CACNA1F | O60840 | 2/20 | 0.39 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.39 |
| ▸ | SCN1A | P35498 | 2/20 | 0.39 |
| ▸ | HTR2B | P41595 | 2/20 | 0.39 |
| ▸ | CACNA1D | Q01668 | 2/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
| ▸ | CACNA1S | Q13698 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL283204 | 0.81 | SMN1; SMN2 (0.42) | SMN1; SMN2ALDH1A1NPSR1MAPTABCC4 | |
| SCHEMBL283122 | 0.80 | SMN1; SMN2 (0.43) | SMN1; SMN2ALDH1A1NPSR1MAPTABCC4 | |
| SCHEMBL27694995 | 0.80 | ALDH1A1 (0.51) | SMN1; SMN2ALDH1A1MAPTABCC4CACNA1F | |
| SCHEMBL283205 | 0.79 | SMN1; SMN2 (0.40) | SMN1; SMN2ALDH1A1NPSR1MAPTABCC4 | |
| SCHEMBL24861312 | 0.78 | SMN1; SMN2 (0.49) | SMN1; SMN2ALDH1A1NPSR1MAPTABCC4 | |
| SCHEMBL26977894 | 0.78 | NQO2 (0.52) | SMN1; SMN2ALDH1A1NPSR1MAPTABCC4 | |
| SCHEMBL283121 | 0.78 | ALDH1A1 (0.47) | SMN1; SMN2ALDH1A1NPSR1MAPTABCC4 | |
| SCHEMBL28196232 | 0.77 | TDP1 (0.44) | SMN1; SMN2ALDH1A1NPSR1TSHRTDP1 | |
| SCHEMBL11871085 | 0.77 | SMN1; SMN2 (0.49) | SMN1; SMN2ALDH1A1NPSR1MAPTABCC4 | |
| SCHEMBL5471856 | 0.76 | BACE1 (0.44) | SMN1; SMN2ALDH1A1NPSR1MAPTABCC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0002624-B1 | 2-BENZAZEPINE COMPOUNDS, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SMITHKLINE BECKMAN CORPORATION (US) | 1981-10-14 | — | — | EP | disclosed |
| EP-0002624-A1 | 2-Benzazepine compounds, processes for their preparation and pharmaceutical compositions containing them | SMITHKLINE BECKMAN CORPORATION (US) | 1979-06-27 | — | — | EP | disclosed |