Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.48 |
| ▸ | GFER | P55789 | 1/20 | 0.48 |
| ▸ | CCND3 | P30281 | 3/20 | 0.48 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.48 |
| ▸ | CDK2 | P24941 | 3/20 | 0.48 |
| ▸ | CCNK | O75909 | 1/20 | 0.48 |
| ▸ | CDK9 | P50750 | 1/20 | 0.48 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | CDK4 | P11802 | 3/20 | 0.46 |
| ▸ | CCND1 | P24385 | 3/20 | 0.46 |
| ▸ | CCND2 | P30279 | 2/20 | 0.46 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6323476 | 0.85 | MEN1 (0.47) | KMT2AMEN1MAPK10GFERCCND3 | |
| SCHEMBL6467426 | 0.83 | MAP3K5 (0.54) | CDK2SMN1; SMN2ALDH1A1HPGDMAP3K5 | |
| SCHEMBL5496713 | 0.82 | CCND3 (0.46) | KMT2AMEN1MAPK10GFERCCND3 | |
| SCHEMBL6402766 | 0.81 | KMT2A (0.47) | KMT2AMEN1MAPK10GFERCCND3 | |
| SCHEMBL27770482 | 0.77 | MAP3K5 (0.60) | KMT2AMEN1CCND3CDK2NPC1 | |
| SCHEMBL31381352 | 0.77 | MAP3K5 (0.60) | KMT2AMEN1CCND3CDK2NPC1 | |
| Benzene SCHEMBL28188863 | 0.77 | MAP3K5 (0.60) | KMT2AMEN1CCND3CDK2NPC1 | |
| SCHEMBL167891 | 0.77 | MAP3K5 (0.60) | KMT2AMEN1CCND3CDK2NPC1 | |
| SCHEMBL1883319 | 0.76 | KMT2A (0.57) | KMT2AMEN1MAPK10GFERCCND3 | |
| SCHEMBL165738 | 0.76 | ROCK1 (0.45) | KMT2AMEN1CDK2SMN1; SMN2CDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021216754-A1 | USE OF P38 MAPK INHIBITORS FOR PREVENTION AND TREATMENT OF AGING AND AGING-RELATED DISORDERS AND FOR BOOSTING AN IMMUNE SYSTEM | Spring Discovery, Inc. (US) | 2021-10-28 | — | — | WO | claimed |
| EP-2286804-A1 | A method of treating degenerative disc disease | DePuy Spine, Inc. (US) | 2011-02-23 | — | — | EP | claimed |
| US-20090162376-A1 | Trans-capsular administration of p38 map kinase inhibitors into orthopedic joints | DEPUY MITEK, LLC | 2009-06-25 | — | — | US | claimed |
| US-20090162351-A1 | Transdiscal administration of inhibitors of p38 MAP kinase | DEPUY SPINE, INC. (US) | 2009-06-25 | — | — | US | claimed |
| JP-2007502327-A | — | — | 2007-02-08 | — | — | JP | claimed |
| CN-1822824-A | Methods of treating degenerative disc disease | DEPUY SPINE INC (US) | 2006-08-23 | — | — | CN | claimed |
| EP-1675589-A2 | TREATMENT OF INFLAMED JOINTS | DePuy Spine, Inc. (US) | 2006-07-05 | — | — | EP | claimed |
| EP-1631266-A2 | A METHOD OF TREATING DEGENERATIVE DISC DISEASE | DePuy Spine, Inc. (US) | 2006-03-08 | — | — | EP | claimed |
| WO-2005011689-A2 | TREATMENT OF INFLAMED JOINTS | DEPUY SPINE, INC. (US) | 2005-02-10 | — | — | WO | claimed |
| US-20050025765-A1 | Trans-capsular administration of high specificity cytokine inhibitors into orthopedic joints | DEPUY SPINE, INC. (US) | 2005-02-03 | — | — | US | claimed |
| WO-2005000283-A2 | A METHOD OF TREATING DEGENERATIVE DISC DISEASE | DEPUY SPINE, INC. (US) | 2005-01-06 | — | — | WO | claimed |
| US-20040229878-A1 | Transdiscal administration of specific inhibitors of P38 kinase | DEPUY SPINE, INC. (US) | 2004-11-18 | — | — | US | claimed |
| US-RE49219-E1 | Local intraosseous administration of bone forming agents and anti-resorptive agents, and devices therefor | DePuy Synthes Products, Inc. (US) | 2022-09-27 | — | — | US | disclosed |
| WO-2021216754-A1 | USE OF P38 MAPK INHIBITORS FOR PREVENTION AND TREATMENT OF AGING AND AGING-RELATED DISORDERS AND FOR BOOSTING AN IMMUNE SYSTEM | Spring Discovery, Inc. (US) | 2021-10-28 | — | — | WO | disclosed |
| US-8986696-B2 | Trans-capsular administration of p38 map kinase inhibitors into orthopedic joints | DEPUY MITEK, INC. (US) | 2015-03-24 | — | — | US | disclosed |
| US-8895540-B2 | Local intraosseous administration of bone forming agents and anti-resorptive agents, and devices therefor | DePuy Synthes Products, LLC (US) | 2014-11-25 | — | — | US | disclosed |
| WO-2005011689-A2 | TREATMENT OF INFLAMED JOINTS | DEPUY SPINE, INC. (US) | 2005-02-10 | — | — | WO | disclosed |
| US-20050025765-A1 | Trans-capsular administration of high specificity cytokine inhibitors into orthopedic joints | DEPUY SPINE, INC. (US) | 2005-02-03 | — | — | US | disclosed |
| WO-2005000283-A2 | A METHOD OF TREATING DEGENERATIVE DISC DISEASE | DEPUY SPINE, INC. (US) | 2005-01-06 | — | — | WO | disclosed |
| US-20040229878-A1 | Transdiscal administration of specific inhibitors of P38 kinase | DEPUY SPINE, INC. (US) | 2004-11-18 | — | — | US | disclosed |