Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.47 |
| ▸ | GFER | P55789 | 1/20 | 0.47 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.47 |
| ▸ | CDK2 | P24941 | 3/20 | 0.47 |
| ▸ | CCND3 | P30281 | 3/20 | 0.47 |
| ▸ | CCNK | O75909 | 1/20 | 0.47 |
| ▸ | CDK9 | P50750 | 1/20 | 0.47 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | FLT3 | P36888 | 1/20 | 0.44 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.44 |
| ▸ | MERTK | Q12866 | 1/20 | 0.44 |
| ▸ | GAS6 | Q14393 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1133352 | 0.85 | KMT2A (0.48) | MEN1KMT2AMAPK10GFERCCNA2 | |
| SCHEMBL4047005 | 0.81 | CDK2 (0.50) | MEN1KMT2ACDK2NPC1RAB9A | |
| SCHEMBL6402766 | 0.77 | KMT2A (0.47) | MEN1KMT2AMAPK10GFERCCNA2 | |
| SCHEMBL6486739 | 0.77 | MKNK1 (0.45) | MEN1KMT2ACCNA2CDK2CCND3 | |
| SCHEMBL4551624 | 0.76 | FLT3 (0.44) | MEN1KMT2AMAPK10GFERCCNA2 | |
| SCHEMBL1883319 | 0.74 | KMT2A (0.57) | MEN1KMT2AMAPK10GFERCCNA2 | |
| SCHEMBL5496713 | 0.74 | CCND3 (0.46) | MEN1KMT2AMAPK10GFERCCNA2 | |
| SCHEMBL1701931 | 0.74 | PDGFRB (0.62) | MEN1KMT2AMAPK10GFERCDK2 | |
| SCHEMBL3951276 | 0.73 | MEN1 (0.67) | MEN1KMT2AMAPK10GFERALDH1A1 | |
| SCHEMBL29544002 | 0.73 | MEN1 (0.67) | MEN1KMT2AMAPK10GFERALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111297867-A | Use of composition containing pyridylaminopyridopyrimidine derivative for preparing medicine for treating breast cancer | 黄泳华 | 2020-06-19 | — | — | CN | claimed |
| CN-110623959-A | Compositions containing mixtures of pyridylaminopyridopyrimidine derivatives and their use | 黄泳华 | 2019-12-31 | — | — | CN | claimed |
| CN-111297867-A | Use of composition containing pyridylaminopyridopyrimidine derivative for preparing medicine for treating breast cancer | 黄泳华 | 2020-06-19 | — | — | CN | disclosed |
| CN-111297867-A | Use of composition containing pyridylaminopyridopyrimidine derivative for preparing medicine for treating breast cancer | 黄泳华 | 2020-06-19 | — | — | CN | disclosed |
| CN-111297867-A | Use of composition containing pyridylaminopyridopyrimidine derivative for preparing medicine for treating breast cancer | 黄泳华 | 2020-06-19 | — | — | CN | disclosed |
| CN-110623959-A | Compositions containing mixtures of pyridylaminopyridopyrimidine derivatives and their use | 黄泳华 | 2019-12-31 | — | — | CN | disclosed |
| CN-110623959-A | Compositions containing mixtures of pyridylaminopyridopyrimidine derivatives and their use | 黄泳华 | 2019-12-31 | — | — | CN | disclosed |
| CN-110623959-A | Compositions containing mixtures of pyridylaminopyridopyrimidine derivatives and their use | 黄泳华 | 2019-12-31 | — | — | CN | disclosed |
| US-6960662-B2 | Process for preparing 2-(4-pyridyl)amino-6-dialkyloxyphenyl-pyrido[2,3-d]pyrimidin-7-ones | WARNER-LAMBERT COMPANY (US) | 2005-11-01 | — | — | US | disclosed |
| US-20030216415-A1 | Process for preparing 2-(4-pyridyl)amino-6-dialkyloxyphenyl-pyrido[2,3-d]pyrimidin-7-ones | BEYLIN VLADIMIR GENUKH (US) | 2003-11-20 | — | — | US | disclosed |
| EP-1307451-A2 | PROCESS FOR PREPARING 2-(4-PYRIDYL)AMINO-6-DIALKYLOXYPHENYL-PYRIDO 2,3-D]PYRIMIDIN-7-ONES | WARNER-LAMBERT COMPANY LLC (US) | 2003-05-07 | — | — | EP | disclosed |
| WO-2002012237-A2 | PROCESS FOR PREPARING 2-(4-PYRIDYL)AMINO-6-DIALKYLOXYPHENYL-PYRIDO[2,3-D]PYRIMIDIN-7-ONES | WARNER-LAMBERT COMPANY (US) | 2002-02-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030216415-A1 | Process for preparing 2-(4-pyridyl)amino-6-dialkyloxyphenyl-pyrido[2,3-d]pyrimidin-7-ones | DPYD, PDXK, PARP2 | MEN1 3451/4885KMT2A 1204/4885MAPK10 3741/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.